مختصر البحث:
Topical drug administration is a technique of applying different dosage forms, including ointments, creams, hydrogels, to the skin and different sections of the body, it has systemic or local effect. Nimesulide is a non-steroidal anti-inflammatory m…
Topical drug administration is a technique of applying different dosage forms, including ointments, creams, hydrogels, to the skin and different sections of the body, it has systemic or local effect. Nimesulide is a non-steroidal anti-inflammatory medication with strong analgesic, and anti-inflammatory properties, it was used in this research and prepared as nanoparticles, which was then incorporated into hydrogel for topical application, to increase solubility of Nimesulide, which is class II in BSC, and reduce their systemic side effects. Nimesulide nanosuspension were prepared by solvent/antisovent method at different polymer: drug ratios (1:1, 2:1, and 3:1) using polymers as polyvinyl pyrrolidone (PVP-K15, PVP-K30), hydroxypropyl methylcellulose (HPMC-E5) and poloxamer-188. The effect of polymer type and concentration on the particle size, poly dispersity index, specific surface area was studied. Among twelve prepared formulas, F2 was selected as best formulas with an average particle size of 59. 5 nm. It was lyophilized and investigated for surface morphology by FESEM, drug–excipients compatibility studies by DSC, crystalline state by XRPD and then Nimesulide nanosuspension of F2(1%w/w Carbopol) was formulated into hydrogel dosage forms and subjected for further evaluation. The results indicated that particle size of nanosuspension was found to be affected by type and concentration of polymer and when increase polymer: drug more than 1:1 led to increase particle size. In addition, the release profile of F2 hydrogel formula was better than plain Nimesulide hydrogel. From this, it is concluded that the dissolution rate of Nimesulide nanosuspension was increased through particle size reduction to nanometer size.
