Insight into adiponectin gene impact on coronary artery disease from a
polymorphism case-control study in Iraqi individuals
الباحث الأول:
Majid Kadhum Hussain
الباحثين الآخرين:
Ibrahem Rahem J. Al-Aadily a, Alhan Abdulmohsin A. Al-Rashid b,
Abdol Hussein A. Algenabi a, Ahmed Naseer Kaftan a, Muna Abdulridha Al-Barqaawi a,
Layth Ahmed A. Al-Fahham a, Teba Jaber Merza c, Iman Jabbar Kadhim a,
Mohammed Ali Abdulameer Khikani d
المجلة:
Gene Reports
تاريخ النشر:
None
مختصر البحث:
Background: Coronary artery disease (CAD) is a group of diseases caused by plaque formation in the wall of
arteries supplying blood to the heart. Adiponectin (ADIPOQ) is an adipocytokine that controls carbohydrate and
lipid metabolism, has anti-di…
Background: Coronary artery disease (CAD) is a group of diseases caused by plaque formation in the wall of
arteries supplying blood to the heart. Adiponectin (ADIPOQ) is an adipocytokine that controls carbohydrate and
lipid metabolism, has anti-diabetic properties, and correlates well with cardio-metabolic risk. ADIPOQ gene
polymorphism is reported to be associated with CAD in numerous populations.
Objective: To explore the impact of adiponectin gene polymorphism, rs2241766 T > G, rs1501299 G > T,
rs17300539 G > A, rs266729 G > A, and rs822395 A > C SNPs, on the CAD in the Iraqi population.
Methods: A case-control study of 317 healthy individuals and 302 CAD patients was conducted. Standard protocols
for measuring serum lipid profile levels were followed. ADIPOQ and insulin levels were estimated using
the ELISA method. Genotyping of ADIPOQ gene was carried out using the RFLP technique.
Results: Genotype assessment of rs2241766, rs1501299, rs266729, and rs17300539 SNPs under several inheritance
models pointed out significant (P = 0.012–10
