Epstein barr virus associated Hodgkin and non-Hodgkin lymphoma
الباحث الأول:
Liqaa Hadi Naser
الباحثين الآخرين:
Kifah Fadhil Hassoon
المجلة:
International Journal of Health Sciences
تاريخ النشر:
None
مختصر البحث:
Background: The Epstein-Barr virus (EBV) has been linked
to a variety of B-cell lymphomas, including Burkitt lymphoma (BL),
classical Hodgkin lymphoma (cHL), and diffuse large B-cell lymphoma
(DLBCL), at rates ranging from 5 to 10% of DLBCL cases…
Background: The Epstein-Barr virus (EBV) has been linked
to a variety of B-cell lymphomas, including Burkitt lymphoma (BL),
classical Hodgkin lymphoma (cHL), and diffuse large B-cell lymphoma
(DLBCL), at rates ranging from 5 to 10% of DLBCL cases to >95% in
endemic BL. Methods: The Present study conducted in AL-Najaf Holy
City; it is a cross sectional study. All patients were recruited from
Middle Euphrates Cancer Research Unit Laboratory, from pre-existing
samples. Tissues collected from the previously mentioned laboratory
were fixed in 10% formalin and placed in a cassette before being
embedded in paraffine. The tissues were examined and diagnosed as
with Hodgkin disease. Eighty samples were subjected in the present
study. All study group was diagnosed formerly as paraffin imbedding
blocks. Molecular analysis also used to detection of EBV-LMP-1 Gene.
Histopathological examination using hematoxylin and eosine stain
(H&E) then examining under light microscope to check for EBV-LMP-1
protein in twenty block samples of tissues with lymphoma. Results:
The result of the current study revealed that EBV-LMP-1 marker
found in 12.5% of cases that had been diagnosed by PCR and IHC
