Histological and physiological study of the effect of silver nano particles and omega-3on Asthma of mice induced by ovalbumine
الباحث الأول:
leena Adeeb Mehdi
الباحثين الآخرين:
Arshad Noori Al-Dujaili
المجلة:
International Journal of Pharmaceutical Quality Assurance
تاريخ النشر:
None
مختصر البحث:
In the current study ninety one of male mice weighting (25-30 g) aged (15-17) weeks at the animal house faculty of science / university of Kufa during the period from January 2017 to September 2017. This study included some physiological and histolo…
In the current study ninety one of male mice weighting (25-30 g) aged (15-17) weeks at the animal house faculty of science / university of Kufa during the period from January 2017 to September 2017. This study included some physiological and histological criteria to evaluate the protective role of omega-3(2 and 3 mg/kg) and silver nanoparticles (5 and 10 mg/kg) against asthma that induced by ovalbumin. The animals experimental are divided into 16 groups (n= 6 mice per each group) for duration of one and two months. The results showed significant increase (p<0.05) in the leukocyte count (eosinophil, neutrophil, lymphocyte, monocyte) in asthma group as compared with control group.Also,the results showed significant decrease (p<0.05) in the leukocyte count in the treated group of omega-3 and silver nanoparticles for both concentration as compared with asthma group. The result sowed significant increase(p<0.05) in the serum level of periostin and Galectin-3 and Interleukin-33 in asthma group as compared with control group. The histological study of lung tissue revealed that induced the tissue with ovalbumin caused necrosis, degeneration and increase of mucous in bronchiole as well as acute inflammation around bronchioles while the effect of ovalbumin in trachea tissue were sluphing, necrosis and degeneration around the epithelium of bronchi oles. © 2018, International Journal of Pharmaceutical Quality Assurance. All rights reserved.
