Effects of Potassium Dichromate on Reproduction and
Fertility in Albino Female Mice
الباحث الأول:
Kareema Habeeb Dohan
الباحثين الآخرين:
Abdul-Hadi Abbas Had
المجلة:
International Journal of PharmTech Research
تاريخ النشر:
8 سبتمبر، 2016
مختصر البحث:
Abstract : The acute toxicity of hexavalent chromium as potassium dichromate (K2Cr2O7) was
studied in female albino mice. Reproductive parameters in ovary and uterus and fertility rate
were evaluated to investigate the possible effects of chromium…
Abstract : The acute toxicity of hexavalent chromium as potassium dichromate (K2Cr2O7) was
studied in female albino mice. Reproductive parameters in ovary and uterus and fertility rate
were evaluated to investigate the possible effects of chromium intoxication. Seventy-five adult
albino mice were used in this study.The mice treated orally with 500 and 1000 ppm of
potassium dichromate that dissolved in tap water for 10, 20, and 30 days. The results of this
study indicated that potassium dichromate produced a significant reduction (P<0.05) in the
weights of body, ovaries, and uterus for treated female mice in comparison with control groups.
Also, there were a significant decrease (P<0.05) in the levels of LH, FSH, and E2 in blood
serum. The findings of present study showed that potassium dichromate induced a significant
decrease (P<0.05) in values of some reproductive parameters including diameters of ovaries
and mature follicles, numbers of ovarian follicles and corpora lutea, and thickness of uterine
layers. Also, the oral administration of female micewith potassium dichromate for 30 days
resulted in a significant reduction (P<0.05) in the number of pregnant females and the number
and weight of litters. Overall, the current study proved that potassium dichromate compound
has a potential toxicity in female reproductive system and fertility of albino mice.
Keywords: Potassium dichromate, Reproductive parameters, Fertility, Ovary, Uterus, Mice.
