SYNTHESIS, CHARACTERIZATION AND ANTIBACTERIAL ACTIVITY OF CHALCONES DERIVATIVES FROM 4-HYDROXYACETOPHENONE AS A STARTING MATERIAL
الباحث الأول:
HUTHAM MAHMOOD YOUSIF AL-LABBAN
الباحثين الآخرين:
RUAA WASSIM ADAM, ISRAA NOOR KADHIM, AHMED ABDULJABAAR JALOOB ALJANABY
المجلة:
International Journal of Advances in Science Engineering and Technology
تاريخ النشر:
12 مايو، 2021
مختصر البحث:
This research involves synthesis of some chalcones derivatives from 4-hydroxyacetophenone as starting material : The derivatives of chalcone compounds [A,B and C] has been prepared by reaction benzaldehyde derivatives like [N,Ndimethylaminobenzaldeh…
This research involves synthesis of some chalcones derivatives from 4-hydroxyacetophenone as starting material : The derivatives of chalcone compounds [A,B and C] has been prepared by reaction benzaldehyde derivatives like [N,Ndimethylaminobenzaldehyde, 3-methoxy4-hydroxybenzaldehyde,4-bromobenzaldehyde] with 4-hydroxyacetophenone .the compound [A,B and C ] derivatives. These compounds [A, B and C ] has been characterized by melting points, [FT.IR] spectroscopy and thin layer chromatography technique (TLC) has been used for reactions steps and sequence by using solvent [benzene : methanol, 4:1]. Biological activity test for three derivative compounds was done according to antibacterial activity test against two multi-drug resistance aerobic pathogenic bacteria: Escherichia coli (E.coli) as gram negative bacteria and Staphylococcus aureus (S.aureus) as gram positive bacteria with four concentrations (50, 100, 150 and 200 mg/ml) for each derivative compounds. The derivative compound C with concentration 200 mg/ml had best antibacterial effect against E.coli and S.aureus with inhibition zone diameters 18.383 ± 0.45182 and 16.700 ± 0.26457, respectively
