Interleukin-39 as a Potential Biomarker of Diabetic Neuropathy: A Case–Control Study with ROC Curve Analysis
الباحث الأول:
Hasan R. Hamood
الباحثين الآخرين:
Hanan R. Hamoud, Fatima Ghazi Talab Al-Tamimi, Hanaa Addai Ali
المجلة:
Chemical Interactions
تاريخ النشر:
12 فبراير، 2026
مختصر البحث:
Background: Diabetic neuropathy is considered the most common prevalent microvascular complication of type 2 diabetes mellitus, manifested by progressive nerve destruction resulting from metabolic and inflammatory mechanisms. The role of IL-39 as a …
Background: Diabetic neuropathy is considered the most common prevalent microvascular complication of type 2 diabetes mellitus, manifested by progressive nerve destruction resulting from metabolic and inflammatory mechanisms. The role of IL-39 as a novel pro-inflammatory mediator in diabetic neuropathy has not been clarified yet. Objective: To assess serum levels of IL-39 and evaluate its clinical diagnostic performance in patients with diabetic neuropathy. Methods: This case-control study recruited patients with diabetic neuropathy and healthy controls. Metabolic, glycemic, lipid, and insulin resistance parameters were assessed. Diagnostic accuracy assessed by serum levels of IL-39 measuring and ROC curve analysis was conducted. Results: High IL-39 levels of significance were recorded in diabetic neuropathy patients compared with healthy controls (P < 0.001). The result of ROC curve analysis shows high diagnostic accuracy, indicating strong discriminatory ability.
