Anti-inflammatory and antioxidant effect of
Empagliflozin on cerebral ischemia/reperfusion injury in rat model
الباحث الأول:
Farqad N. Abed
الباحثين الآخرين:
Ebtihal C. Abbas , Hasanain A. Al-Khalidi , Ahmed M. AlMudhafar , Najah R. Hadi
المجلة:
European Journal of Molecular and Clinical Medicine
تاريخ النشر:
None
مختصر البحث:
Background: Restriction of cerebral blood flow can disturb cellular homeostasis due to insufficient oxygen and nutrient delivery. However, the re-establishment of cerebral blood flow can aggravate the impairment of ischemic brain tissue contributing…
Background: Restriction of cerebral blood flow can disturb cellular homeostasis due to insufficient oxygen and nutrient delivery. However, the re-establishment of cerebral blood flow can aggravate the impairment of ischemic brain tissue contributing to a series of oxidative, inflammatory events resulting in cerebral ischemia-reperfusion (CI/R) injury, which eventually results in neuronal death and neurological disability. Method: An experimental model of 30 Sprague-Dawley rats were randomly allocated to five groups, sham group, I/R group, I/R+(DMSO as a vehicle),I/R+ intraperitoneal (i.p) Empagliflozin 5mg/kg 1 hour before induction of BCCAO, and I/R+ intraperitoneal Empagliflozin 10mg/kg 1hour before induction of BCCAO. The brain tissue levels of IL-1β, ICAM-1, and F2-isoprostane were measured in each group in our study. Results: The two doses of (5mg/kg and 10mg/kg) Empagliflozin were significantly reduced the brain tissue level of IL-1β, ICAM-1, and F2-isoprostane as compared to I/R and I/R+vehicle groups. Conclusions: From the results above we concluded that Empagliflozin has a neuroprotective effect seeing that it’s anti inflammatory and anti-oxidant activity.
