مختصر البحث:
This research involved synthesis heterocyclic compounds such as (1,3,4- thiadiazole derivatives , imidazolidine
derivatives, tetrazole derivatives, oxazepine derivatives and β-Lactam derivatives ) were prepared by reaction 4-
aminobenzoic acid wit…
This research involved synthesis heterocyclic compounds such as (1,3,4- thiadiazole derivatives , imidazolidine
derivatives, tetrazole derivatives, oxazepine derivatives and β-Lactam derivatives ) were prepared by reaction 4-
aminobenzoic acid with phenol in Acidic medium ,(0-5)CO
and sodium nitrate to get azo derivative (1) which react
with thiosemicarbazide to get 1,3,4- thiadiazole derivative (2). Derivative (2) react with benzaldehyde derivatives
(4-nitrobenzaldehyde , 2-hydroxy benzaldehyde , 2-bromobenzaldehyde , 4-hydroxybenzaldehyde ,benzaldehyde ,4-
dimethyl amino benzaldehyde, 4-Chlorobenzaldehyde and vanillin) to get shiff base (3-10). The cyclization of Shiff
base Derivatives (3,4) with α-aminoacid (tryptophan and leucine) Consecutive give the corresponding imidazolidine
derivatives (11,12),and when cyclization of Shiff base Derivative (5) with sodium azide give tetrazole derivative
(13). Shiff base Derivatives (6,7,8) react with (Itaconic, succinic anhydride and malic anhydride ) Co nsecutive to
give oxazepine derivatives (14,15,16) Consecutive. cyclization of Shiff base Derivatives (9,10) with
chloroacetylchloride give the corresponding β-lactam (17,18). All this compounds characterized by means of FTIR, and some of the compoundes by means 1H-NMR, and 13C-NMR and follow reaction by Rf - TLC and Measure
ment melting point.
Key words: Thiadiazole, Thiazolidin, Imidazolidin, tetrazole, oxazepine β-Lactam
