Immunohistochemical expression of
Aromatase in malignant breast tumors
الباحث الأول:
Rawaa Abdul-Ameer Abdul-Jabbar
الباحثين الآخرين:
Hanan D. Abbass
Farha A. Ali Shafi
المجلة:
Iraqi Journal
of Cancer
and Medical
Genetics
تاريخ النشر:
None
مختصر البحث:
Abstract:
Twenty tumour biopsies of Iraqi breast cancer female patients were examined for immunohistochemical (IHC) expression
of aromatase. The expression was correlated with age and histopathological type, grade and clinical staging of tumour.
…
Abstract:
Twenty tumour biopsies of Iraqi breast cancer female patients were examined for immunohistochemical (IHC) expression
of aromatase. The expression was correlated with age and histopathological type, grade and clinical staging of tumour.
Results revealed that out of the 20 investigated cases, 75.0% showed positive IHC expression of aromatase, which was distributed
as 35.0% for score 2+ and 40.0% for score 3+. The remaining five negative cases (25.0%) were observed to have the
lowest age mean (38.6 ± 4.4 years), which was significantly different from the recorded age mean in patients with the score
2+ (53.6 ± 3.2 years; p = 0.008) or 3+ (49.4 ± 2.8; p = 0.04), but no significant difference was observed between age means
of positive cases. A histpathological examination of tumours revealed that they were invasive ductal carcinoma (IDC) but of
two types: tubular IDC (5 cases; 25.0%) and 15 cases (75.0%) were defined as not otherwise specified (IDC-NOS). In tubular
IDC, most of cases (80.0%) had 3+ score, while in IDC-NOS, it was 26.7%. Such difference was significant (p = 0.023).
Distributing patients by grade and stage of tumours revealed no significant difference in IHC scoring of aromatase or age. It
is possible to conclude that positive IHC expression of aromatase is tended to occur in older ages (around 50 years) of breast
cancer patients.
Keywords: Immunohistochemical expression, Aromatase, Breast cancer
