Synthesis, Characterization, and Antibacterial Study of New Ligands Derived from Nalidixic acid
الباحث الأول:
Dunya AL-Duhaidahawi1
الباحثين الآخرين:
Hanaa Jaffer AlKabee2 Meison Abdulbary3, Hayder H. AL-Ghuraibawi4
المجلة:
Systematic Review Pharmacy
تاريخ النشر:
None
مختصر البحث:
A novel compounds of nalidixic acid derivatives were synthesized by a
coupling reaction with 2-aminothiazole-5-carbaldehyde using DIC as
coupling reagent and HOBt as racemization suppressant then the
product of reaction treated with different ami…
A novel compounds of nalidixic acid derivatives were synthesized by a
coupling reaction with 2-aminothiazole-5-carbaldehyde using DIC as
coupling reagent and HOBt as racemization suppressant then the
product of reaction treated with different amine tail like 2-(methylthio)
Ethan amine that result in compound 1 while refluxing with 2-(4-methyl
piperazine-1-yl) Ethan amine and 2-(pyrrolidine-1-yl) Ethan amine results
in compound 2 and 4 respectively. All the synthesized compounds were
adequately identified by spectral studies utilizing IR and elemental
analysis and assessed for their in vitro antibacterial activity in
contradiction of different type of bacteria. All the tested molecules
against bacterial strains compared with the nalidixic acid as a reference
drug in this study. Results indicated that compounds 1, 2 & 4 have good
antibacterial activities compared to standard drug especially as they
were found to have promising activity against Bacillus and to be as
effective as nalidixic acid toward psudomonus and E coli.
