مختصر البحث:
This research involves synthesis of some new 1,2,3-triazoline and 1,2,3,4-tetrazole derivatives from benzotriazole as
starting material. The first step includes formation of 1-(1H-benzo[d][1,2,3]triazol-1-yl)-2-chloroethanone[A]
through reaction o…
This research involves synthesis of some new 1,2,3-triazoline and 1,2,3,4-tetrazole derivatives from benzotriazole as
starting material. The first step includes formation of 1-(1H-benzo[d][1,2,3]triazol-1-yl)-2-chloroethanone[A]
through reaction of benzotriazole with chloroacetyl chloride and triethylamine in DMF. Then reaction of [A] with
sodium azide in DMF to form 2-azido-1-(1H-benzo[d][1,2,3]triazol-1-yl) ethanone [B]. Chalcone derivatives [ch1-
ch6] have been prepared from reaction acetophenone with benzaldehyde derivatives like [4-nitro benzaldehyde,
4-(dimethylamino)benzaldehyde, 4-hydroxy-3-methoxybenzaldehyde, 4-chlorobenzaldehyde, 4-bromobenzaldehyde
and 3-hydroxybenzaldehyde], While Schiff bases [S1-S10] were prepared from condensation of [para-toluidine,
benzidine, naphthylamine] with [4-nitro benzaldehyde, 4-(dimethyl amino)benzaldehyde, 4-hydroxy-3methoxy
benzaldehyde ,4-chloro benzaldehyde, 4-bromobenzaldehyde and 3-hydroxybenzaldehyde] in absolute ethanol.
Compound [B] was entered in 1,3-dipolar cycloaddition reactions with some of α,β-unsaturated carbonyl
compounds like [chalcones (ch1-ch6) , Acryl amide, Methyl acrylate, Cinnamic acid,1,4-Benzoquinone and Maleic
anhydride] and Schiff bases to give 1,2,3-triazoline[Bch1-Bch6, C, D, E, F, G] and 1,2,3,4-tetrazole derivatives [BS1-
BS10]. All these compounds are characterized by [FT.IR] spectroscopy, and sequence of reactions step by [TLC]
technique, by using solvent (benzene-methanol, 4:1). Some of them are characterized by [1HNMR] spectroscopy and
elemental analysis [C.H.N.S].
