Biochemistry, Pathophysiology and Clinical Significance of Lactoferrin: A Review Article
الباحث الأول:
غفران سلمان عبد الحسين
الباحثين الآخرين:
ناديه حبيب سرحان ,بيداء ريحان علي ,علي عبد الزهره الفحام
المجلة:
International Journal of Medical Science and Dental Health
تاريخ النشر:
17 يوليو، 2025
مختصر البحث:
Lactoferrin is a multi-iron binding functional glycoprotein with significant clinical applications in the treatment ofinfectious diseases, inflammatory disorders, cancer, neonatology, and metabolic conditions. Its normal functioninvolves high affini…
Lactoferrin is a multi-iron binding functional glycoprotein with significant clinical applications in the treatment ofinfectious diseases, inflammatory disorders, cancer, neonatology, and metabolic conditions. Its normal functioninvolves high affinity iron sequestration complementary direct microbial membrane interactions making it animportant part of the innate immune system. Clinically proven effective in lactoferrin supplementation to reduceneonatal infections on sepsis as well as necrotizing enterocolitis; this will be a promising prophylactic approach forpreterm infants. Its antiviral activity broadens even more its therapeutic potency regarding emerging viral infectionsincluding some preliminary applications on COVID-19. It is reported that the immunomodulatory lactoferrin regulatesboth processes by controlling cytokine production and cell function. Fecal lactoferrin is an easy-to-apply inflammationmarker within the intestines for inflammatory bowel disease besides being helpful in monitoring how well treatmentis working. Apart from these functions, lactoferrin can exert anticancer activity via antiproliferative, pro-apoptotic aswell as anti-angiogenic mechanisms. Newer evidences also support its application as an adjuvant in cancer therapy.Additionally, lactoferrin has a role in neonate development through gut maturation plus immune system education.Disorder management, especially metabolic, cardiovascular, and diabetic related disorders, seems to be wherelactoferrin aces it by modulating iron homeostasis plus reducing oxidative stress. The challenges of the bioavailabilityand standardized preparations of lactoferrin limit the therapeutic promise it holds. Further advances in deliverytechnologies, together with expanded clinical trials, are needed to optimize its use
(PDF) Biochemistry, Pathophysiology and Clinical Significance of Lactoferrin: A Review Article. Available from: https://www.researchgate.net/publication/394014128_Biochemistry_Pathophysiology_and_Clinical_Significance_of_Lactoferrin_A_Review_Article [accessed Oct 23 2025].
