Subclinical hypothyroidism with preeclampsia
الباحث الأول:
Alaa M. Sadiq,
الباحثين الآخرين:
*Maitham G. Yousif , Fawz A. mohammed , Saba H. Aladly,
Hawraa H. Hameed.
المجلة:
research journal of pharmaceutical, biological and chemical sciences
تاريخ النشر:
None
مختصر البحث:
Preeclampsia is a multi-systemic disorder, unique to pregnancy, that may complicate 5-10% of all pregnancies .It has a multi factorial theories regarding its etiology that is why it can affect many organs in the body including thyroid gland. Hypothy…
Preeclampsia is a multi-systemic disorder, unique to pregnancy, that may complicate 5-10% of all pregnancies .It has a multi factorial theories regarding its etiology that is why it can affect many organs in the body including thyroid gland. Hypothyroidism Complicates 1% of pregnancies, most commonly due to iodine deficiency so it is more likely to occur in women in areas of endemic iodine deficiency or Hashimoto’s thyroiditis in developed world. Subclinical hypothyroidism is an entity when thyroid function is only mildly affected, indicated by normal level of thyroxin and elevation of TSH. This cross-sectional study was carried out in AL-Zahra maternity and pediatric teaching hospital in AL-NAJAF city during the period between 1st of May, to 10thof October 2015.The patients were recruited from Labor room as a total of 128 patients (30 with no history of hypertension, 45severe preeclampsia, 53 mild preeclampsia). For each patient proper history was taken regarding age, gestational age, parity, previous history of thyroid disorder, current history of hypertension and past medical history. The participants were divided into 3 groups with (no, mild, and severe) PE. There was no statistically significant difference among groups regarding age ,gestational age (P>0.001)while the difference was significant difference among them in relation to Systolic BP, Diastolic BP, BMI, Platelet, SGOT, SGPT, B. urea, S. uric acid and S. Creatinine ( P<0.001). Highly significant difference in weight of neonate and APGAR score was observed among women with high TSH than women with normal TSH (P value< 0.001).The level of TSH is increasing significantly with increasing maternal age and with increasing severity of PE (P<0.001). The 3 groups showed no statistically significant difference in the level of free T4. It was observed that there was strong association between high TSH level and development of PE (100% association). Cases with severe PE were found to be associated with subclinical hypothyroidism(elevated TSH level) rather than mild cases.
Keywords: Pregnancy; Preeclampsia; Severe preeclampsia; Subclinical hypothyroidism.
