1,2,3-TRIAZOLIUM SALTS DERIVATIVES AS ANTICANCER REAGENTS
الباحث الأول:
Ali Jabbar Radhi
الباحثين الآخرين:
Farked Wahoodi Salman,3 Jawad Kadhim Alshamsa2, Mustafa Kadhum Naeem1, Muhand Dohan Abd-Zaid1, Ahmed Wheed Radhi,4 Zaman Abdalhussein Ibadi Alaridhee5,
المجلة:
World Bulletin of Public Health (WBPH)
تاريخ النشر:
3 يوليو، 2023
مختصر البحث:
A group of organic compounds known as 1,2,3-triazolium salts includes the following:
triazolium cation, a five-membered ring made up of three nitrogen and two
carbon atoms. Due to their wide spectrum of characteristics and prospective
uses in che…
A group of organic compounds known as 1,2,3-triazolium salts includes the following:
triazolium cation, a five-membered ring made up of three nitrogen and two
carbon atoms. Due to their wide spectrum of characteristics and prospective
uses in chemistry, materials science, and medicine, these compounds have
attracted a lot of attention in recent years. The triazolium ring's substituents can
be changed to create derivatives of 1,2,3-triazolium salts. The type and location
of these substituents have a significant impact on the compound's characteristics
and reactivity. Some 1,2,3-triazolium salt compounds have demonstrated strong
biological activity, including antibacterial, antifungal, and anticancer activities.
This makes them potential candidates for the development of new drugs and
therapies. 1,2,3-Triazolium salts derivatives have shown potential as anticancer
reagents due to their ability to selectively target cancer cells and inhibit their
growth. These derivatives exhibit cytotoxicity towards cancer cells while
demonstrating minimal toxicity towards normal healthy cells. This review
provides a comprehensive overview of synthetic strategies for the preparation
of 1,2,3-triazolium salts and highlights the structures of various derivatives that
exhibit biological activities (anti-cancer). It is important to note that the
development of 1,2,3-triazolium salts derivatives as anticancer reagents is an
active area of research, and specific compounds and mechanisms may vary.
Further studies are required to optimize their efficacy, selectivity, and safety
profiles before their clinical application.
