مختصر البحث:
_____________________________
#Ph.D-Student;
*Corresponding author;
Original Research Article
UTTAR PRADESH JOURNAL OF ZOOLOGY
43(12): 1-15, 2022
ISSN: 0256-971X (P)
PREPARATION, CHARACTERIZATION AND STUDY OF
THE BIOLOGICAL SCREENING OF TH…
_____________________________
#Ph.D-Student;
*Corresponding author;
Original Research Article
UTTAR PRADESH JOURNAL OF ZOOLOGY
43(12): 1-15, 2022
ISSN: 0256-971X (P)
PREPARATION, CHARACTERIZATION AND STUDY OF
THE BIOLOGICAL SCREENING OF THE AU (III) COMPLEX
WITH NOVEL (AZO -SCHIFF BASE) LIGAND
J. J. EMMAN a*#, LAYLA ALI MOHAMMED b AND KHALIDA KADHIM ABBAS c
a Faculty of Pharmacy, Pharmaceutical Chemistry Branch, Iraq.
b Department of Chemistry, College of Education for Girls, University of Kufa, Iraq.
c Clinical Laboratory, Sciences Department, Faculty of Pharmacy, Kufa University, Iraq.
AUTHORS’ CONTRIBUTIONS
This work was carried out in collaboration among all authors. Authors JJE, LAM and KKA managed the
research. Authors JJE, LAM and KKA done the research and wrote the main manuscript text. Authors JJE,
LAM and KKA prepared tables and wrote a part of manuscript text. All authors read and approved the final
manuscript.
Article Information
Editor(s):
(1) Dr. Telat Yanik, Atatürk University, Turkey.
Reviewers:
(1) Bogdan-Alexandru Hagiu, Alexandru Ioan Cuza University from Iasi, Romania.
(2) S. P. Indra Kumar, Vivekanandha Dental College for Women, India.
(3) Leili mohammadi, Zahedan University of Medical Sciences, Iran.
Received: 07 April 2022
Accepted: 14 June 2022
Published: 20 June 2022
ABSTRACT
The Aim: Biological studies carried out of new gold complexes after its preparation.
Place and Duration of Study: All preparations were carried out in college of education, chemistry lab between
(Jan 2021 to May 2022).
Study Design: New azo –Schiff base ligand 2-amino-3-(2-((3-((2-hydroxy-4-sulfamoylphenyl)imino)-1,5-
dimethyl- 2-phenyl- 2,3-dihydro- 1H-pyrazol-4-yl) diazenyl) -1H-imidazol-4-yl)propanoic acid with chelate
complexes of Co(II),Ni(II), Cu(II), Zn(II), Cd(II) , Hg(II) and Au(III) were prepared with metal salts in ethanol
a solvent in 1:1 ratio (metal : ligand) . The azo-Schiff base ligand has been synthesized from condensation of 2-
amino-3- (2-((3-( (2 -hydroxy- 4-sulfamoylphenyl) imino)- 1,5-dimethyl -2-phenyl-2,3-dihydro-1H-pyrazol-4-
yl)diazenyl)-1H-imidazol-4-yl)propanoic acid with 4-amino-3-hydroxybenzenesulfonamide.
Methodology: The prepared azo Schiff ligand and its metal complexes where checked by different spectral
technique as, FT-IR ,C.H.N elemental analyses , Atomic absorption, magnetic moment measurements, molar
conductance, UV-vis, ,1H-NMR and mass spectra studies.
Results: The data show that the complexes have the composition of 1:1[M:L] chelates type and octahedral
geometry with each of Co(II), Ni(II),Cu(II),Zn(II), Cd(II) and Hg(II) ions, except for Au(III) ion which has
square planer geometry. All complexes that non electrolytes and no conductive species but Au(III) complex is
1:2 electrolyte nature. This can support the electrolytic nature of the metal complex
