مختصر البحث:
COVID-19, caused by SARS-CoV-2, has unresolved mortality risk factors and clinical course,
highlighting the need for further research. Aims: The study aimed to asses D-dimer and C-Reactive Protein (CRP)
as the risk factors for severity covid-19…
COVID-19, caused by SARS-CoV-2, has unresolved mortality risk factors and clinical course,
highlighting the need for further research. Aims: The study aimed to asses D-dimer and C-Reactive Protein (CRP)
as the risk factors for severity covid-19 and who are less capable of surviving. Methods: A retrospective study
conduct of COVID-19 in adult inpatients aged >20 at Al-sadder and Alamal Hospital in Iraq. Demographics, clinical
trials, treatments, and viral RNA samples were analyzed. The study involved 100 patients, with 67 discharged
and 33 hospitalized died. The majority of the participants 45% were aged < 40, but 55% were aged >40 years.
Results: A significant and 57% were male 37(55.2%) Survivor vs. 20 (60.6%) non-survivor, p=0.024), more than
43% were female (30(44.8%) Survivor vs. 13(39.4%) non-survivor, p=0.010. Patients had underlying
comorbidities (66%), survivor 37(55%), and non-survivor 29(87%). The most prominent comorbidity in non
survivors more than survivors was diabetic mellitus 85%, asthma 58%, stroke 48%, renal failure 42%, heart strake
33%, and hypertension 18%. The study found significant differences in WBC, lymphocyte count, D-dimer, Ferritin,
CRP, and LDH levels in non-survivors compared to survivor patients, with a positive correlation between D- dimer
and these parameters. The ROC analysis curve showed CRP with a high AUC of 80.2%, 87.9% sensitivity, and
37.3% specificity, while D-dimer and LDH had AUCs of 0.74.9 and 70%, respectively. Discussion: The study
found that older age, higher d-dimer, ferritin, CRP, and LDH are associated with disease severity and higher
mortality risk in adult COVID-19 patients. Conclusions: These biomarkers could aid in early detection of disease
progression signs and better patient management
