مختصر البحث:
Aluminum hydroxide nanoparticles have been employed in many industries, which are widely abundant in
many aspects of human life. The role of the aluminum hydroxide nanoparticles adjuvant is to enhance the
immune response. However, the impact of na…
Aluminum hydroxide nanoparticles have been employed in many industries, which are widely abundant in
many aspects of human life. The role of the aluminum hydroxide nanoparticles adjuvant is to enhance the
immune response. However, the impact of nanoparticles exposure has not been perfectly investigated yet.
Accordingly, some questions have been raised about their potentially harmful effects, based on which the
current research aims to answer them. This study aimed to investigate the histological effects of aluminum
hydroxide nanoparticles and bulk-aluminum hydroxide (bulk Al[OH]3) on the liver, lung, heart, and kidney
tissues. For this reason, an experiment was implemented on the aluminum hydroxide nanoparticles adjuvant in
five neonatal mice. Intramuscularly, the mice were injected with 0.125 mL of adjuvanted vaccine, while five
neonatal mice were injected with bulk and nanoparticles of Al (OH)3 and then sacrificed after one and two
months, respectively. Vaccines were controlled by evaluating the histopathological response in neonatal mice.
Subsequently, the pathological effect of both adjuvants was surveyed using the histological study of the lung,
liver, heart, and kidney of the animals. The obtained recorded data indicated that both types of vaccine adjuvants
caused pathological lesions on the histology sections of the liver, lung, heart, and kidney tissues. Moreover, bulk
Al (OH)3 adjuvant vaccine was more effective and had a higher pathological response than aluminum hydroxide
nanoparticles adjuvant vaccine. In addition, the total DNA content in both groups was estimated using
Fluorometer from Promega. Compared to aluminum hydroxide nanoparticles groups, the tissues indicated a
decrease in total DNA content obtained in bulk Al (OH)3 groups. Therefore, it can be concluded that the
exposure to aluminum hydroxide nanoparticles would result in less pronounced toxicity, as well as systemic
inflammation, compared to the bulk Al (OH)3 aluminum hydroxide.
