مختصر البحث:
The objective of the present study was to compare the beneficial effects of vitamins C and E on Lincomycin-induced
hepatotoxicity and nephrotoxicity. Sixteen of male albino rats sexually matured were randomly divided into four
groups: (i) control,…
The objective of the present study was to compare the beneficial effects of vitamins C and E on Lincomycin-induced
hepatotoxicity and nephrotoxicity. Sixteen of male albino rats sexually matured were randomly divided into four
groups: (i) control, (ii) Lincomycin (500 mg/kg) administrated orally, (iii) Lincomycin plus vitamin C (500 mg/kg) and
vitamin E (400 mg/kg), (iv) vitamin C plus vitamin E were administrated orally at the same doses of third group.
Lincomycin treatments were started directly (1) day after the first administrations of these vitamins and continued for
(21) days. At the end of the experiments: body weight, liver, kidney and spleen relative weights, erythrocytes
sedimentation rate, urea, total bilirubin, creatinine, malondialdehyde, glutathione, total cholesterol, triglycerides, low
density lipoproteins, liver enzyme activities ALP, AST and ALP were significantly increased (p <0.05) in Lincomycin
treated group, while haemoglobin concentration, packed cell volume, white blood cell counts, high density lipoproteins
were significantly decreased (p <0.05) in the same group when compared with the three other groups: control ,
vitamins ,Lincomycin and vitamins groups. Vitamins C and vitamin E were suppressed the oxidative stress of
Lincomycin which used in this study, so the data of the present study suggest that, vitamin C and vitamin E could be
useful for reducing the detrimental effects of Lincomycin-induced toxicity on liver and kidneys.
