Computational Investigation of the Impact of the Ghrelin Hormone Gene
Variation (R51Q) on the Hormone-receptor Binding Pattern
الباحث الأول:
BARAA ADIL HADI
الباحثين الآخرين:
Saleha Shahar, Syazwani I. Amran, Mohd S. S. Omar, M. Abu Naser
المجلة:
UTM
تاريخ النشر:
25 مارس، 2023
مختصر البحث:
Ghrelin is a peptide hormone made up of 28 amino acids. It is involved in various biological processes, including the stimulation
of growth hormone release, control of food intake, and metabolic and cytoprotective effects. In 1999, this hormone was…
Ghrelin is a peptide hormone made up of 28 amino acids. It is involved in various biological processes, including the stimulation
of growth hormone release, control of food intake, and metabolic and cytoprotective effects. In 1999, this hormone was identified
as a ligand for the GHSR1a growth hormone secretagogue receptor. Ghrelin hormone-receptor complexes have been modeled
in a few previous in-silico studies, but none of them have investigated the effects of the gene variation rs34911341/(R51Q)
on the full-length ghrelin model and on the hormone-receptor binding. It was established that the full-length ghrelin model’s
secondary structure was unaffected by the R to Q amino acid substitution. Additionally, the mutant hormone-receptor complex
exhibited better outcomes and altered the molecular interactions between the mutant ligand and the receptor by creating novel
interactions, according to the post-molecular dynamic simulation analysis.
