PREPARATION AND CHARACTERIZATION OF ORODISPERSIBLE TABLETS OF CANDESARTAN
CILEXETIL BY DIRECT COMPRESSION METHOD
الباحث الأول:
ATHEER MOHAMMED JASEM
الباحثين الآخرين:
MOWAFAQ MOHAMMED GHAREEB
المجلة:
International Journal of Pharmacy and Pharmaceutical Sciences
تاريخ النشر:
None
مختصر البحث:
Objective: Candesartan cilexetil (CC) is a selective AT1 subtype angiotensin II receptor antagonist and candesartan is widely used in treatment of
diseases like hypertension, heart failure, myocardial infarction and diabetic nephropathy. The object…
Objective: Candesartan cilexetil (CC) is a selective AT1 subtype angiotensin II receptor antagonist and candesartan is widely used in treatment of
diseases like hypertension, heart failure, myocardial infarction and diabetic nephropathy. The objective of this study was to prepare and evaluate
orodispersible tablets of candesartan cilexetil using direct compression method. The orodispersible tablets (ODT) as recently developed drug
delivery system is a solution for many problems faced by patients especially the pediatric and geriatrics.
Methods: The tablets were made using different superdisintegrant [Sodium Starch Glycolate (SSG) and Croscarmellose Sodium (CCS), and
Crospovidone (CP)] at three different percentages, in addition to sweetening agent (aspartame) with microcrystalline cellulose (MCC) and mannitol
as diluents. Formulated orodispersible tablets were evaluated for weight variation, friability, disintegration time, drug content, wetting time, water
absorption ratio and in vitro drug release.
Results: The results show that the presence of a superdisintegrant and MCC is desirable for orodispersion. Although all the formulations satisfied
the limits of orodispersion with a dispersion time of less than 48 sec but formula (F8) that contain 10% crospovidone as superdisintegrant with
30% MCC shows the best results regarding disintegration time of 13 sec, hardness of 3.5 kg/cm2, and fast drug release rate of 100% within 10 min,
as compared with the conventional tablet (35%).
