Protective Impact of Vitamin C Against Some Fetal and
Neonatal Congenital Malformations and Anti-
Inflammatory Non-Steriodal –Induced Hepatotoxicity of
White Rats
الباحث الأول:
Dalal Abdel-Hussein Kadhim AL– Essawia
الباحثين الآخرين:
Ashwaq K. Abedb, Wadad Yahya Hashemc, Assel Said
Ismaal Alhadadd, Zainb Majid Mohammde
المجلة:
A multifaceted review journal in the field of pharmacy
تاريخ النشر:
None
مختصر البحث:
The current study was designed to demonstrate the
protective impact of vitamin C against some fetal and
neonatal congenital malformations and antiinflammatory
non-steriodal–induced hepatotoxicity in
them of white rats ,this study was carried out…
The current study was designed to demonstrate the
protective impact of vitamin C against some fetal and
neonatal congenital malformations and antiinflammatory
non-steriodal–induced hepatotoxicity in
them of white rats ,this study was carried out in animal
house of biology department in Education Faculty for
Girls -Kufa university from 1/11/2019 to 15/3/2020, 24
white female rats with age ranged between (11-12) weeks
and weights ranged between (230-240) kg, in adition to
(24) white male rats with ages between (9-11) weeks for
mating, the female and male rats were placed together
for mating, after obtaining the required number of
pregnant female rats, these pregnant rats were
distributed to 4 groups , each group included 6 pregnant
rats ,the group1 was treated with normal saline solution
and was the control group, group2 was treated with
indomethacin drug with a concentration of 8.40 mg / kg
of body weight, while group 3,4 were treated with
vitamin C with a concentration of 85 mg /kg of body
weight and vitaminC with a concentration of 85 mg / kg
of body weight + indomethacin drug with a
concentration of 8.40 mg / kg of body weight
respectively, pregnant female rats in all groups were
treated orally from the first day of pregnancy, 3 pregnant
rats were dissected during 20 days of pregnancy, while
the remaining 3 pregnant rats were left to after birth of
each group.
The results of the this study pointed to that a significant
decrease (P <0.05) in numbers of total and living of the
embryos for pregnancy period (20) days and newborns
