Microwave-Assisted Synthesis of Five and Seven-Membered Heterocycles from Ibuprofen and Study Their Biological Activity
الباحث الأول:
اشواق عباس علي
الباحثين الآخرين:
نادية صادق مجيد
المجلة:
Journal of Kufa for Chemical
Science
تاريخ النشر:
None
مختصر البحث:
The carboxylic acid group of ibuprofen, which is responsible for some of its side effects, is converted into a hydrazide group by reacting it with hydrazine. the hydrazide then reacts with specific aldehyde to create highly active Schiff base. These…
The carboxylic acid group of ibuprofen, which is responsible for some of its side effects, is converted into a hydrazide group by reacting it with hydrazine. the hydrazide then reacts with specific aldehyde to create highly active Schiff base. These Schiff bases react with certain amino acids to form imidazolidinone molecules(K7-K10). Schiff bases also react with anhydrous acids and hydroxy succinimide to produce seven-membered heterocyclic rings (K3-K6) The synthesized compounds were tested against two types of bacteria at various concentrations. .
These new compounds showed significant antibacterial efficacy, while ibuprofen itself exhibited no activity against the bacteria The melting points of the new compounds were found to be higher than ibuprofen,indicating greater stability. Additionally, the new compounds exhibited improved solubility due to the formation of intramolecular and intermolecular hydrogen bonds.unlike ibuprofenwhichhaspoorwatersolubility. .
