Ukufa

البحوث المنشورة

Genetic aspect of Iraqi pregnant women with pre- eclampsia

الباحث الأول: Salih Alkhafaji A

الباحثين الآخرين: nwar AljanabiAnwar AljanabiBasimaal-GhzalyShehab FarisShehab Faris

المجلة: International Journal of Science and Research

تاريخ النشر: None

مختصر البحث:

Introduction: One of serious problems of pregnancy complication is the Pre-eclampsia syndrome (PE) which mostly leads to increase-1568 morbidity and mortality in mother and fetus. Objective: we aimed to study and evaluate the genetic polymorphism co…

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Connexin 26 (GJB2) gene mutations linked with autosomal recessive non-syndromic sensor neural hearing loss in the Iraqi population

الباحث الأول: Anwar Madlool Al-janabi

الباحثين الآخرين: Habeeb Shuhaib Ahmmed , Salih Mahdi Al-Khafaji

المجلة: JOURNAL of MEDICINE and LIFE

تاريخ النشر: None

مختصر البحث:

Deafness is a total or partial hearing loss that may appear at any age and with different degrees of severity. Approximately 50% of hearing loss have a genetic origin, and among them, non-syndromic sensorineural deafness represents about 70% of t…

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Association of Vitamin D Receptor-FOKI Gene Polymorphism with Breast Cancer Risk in Iraqi Female Patients

الباحث الأول: Anwar M. Al-Janabi1

الباحثين الآخرين: Abdul Hussein A. Algenabi2, Salih M. Alkhafaji3

المجلة: International Journal of Science and Research (IJSR)

تاريخ النشر: None

مختصر البحث:

Abstract: Background: Breast cancer is the most frequent cancer among women worldwide. In Iraq, it is accounting about one third of the registered women cancers. Different studies have shown that the gene polymorphism in vitamin D receptor (VDR-FOKI…

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Prevalence of Y chromosome microdeletion in azoospermic infertile males of Iraqi population

الباحث الأول: ANWAR M. AL-JANABI

الباحثين الآخرين: ALI IBRAHIM RAHIM2, SHEHAB A. FARIS2, SALIH M. AL-KHAFAJI2 and DHAFER JAWAD3

المجلة: Journal of Genetics

تاريخ النشر: None

مختصر البحث:

Abstract. In human gamete development, the important period is spermatogenesis, which is organized by specific genes on Y chromosome. In some cases, the infertile men have shown microdeletions on Y chromosome, which seemed as if the structural chro…

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Polymorphism of Vitamin D Receptor (re2228570) in Sera of Coronary Artery Diseases and its Association with Various Anthropometric and Biochemical Parameters

الباحث الأول: Siham Abdul Zahra Rahi

الباحثين الآخرين: Fadhil Jawad Al-Tu’ma1; Anwar Madlool Al-Ganabi2 And Jawad F. Al-Tu’ma3

المجلة: AL-Qadisiya Medical Journal

تاريخ النشر: None

مختصر البحث:

Abstract Objective : Coronary artery disease is increasing and accounts for a high proportion among others diseases. In Iraq various studies have been reported that the polymorphism of vitamin D receptor VDRFok I gene like rs 2228570 are associat… Abstract Objective : Coronary artery disease is increasing and accounts for a high proportion among others diseases. In Iraq various studies have been reported that the polymorphism of vitamin D receptor VDRFok I gene like rs 2228570 are associated with CAD patients. Aim: This study was aimed to investigate the association between the SNP of VDR Fok I (rs2228570) gene with various anthropometric and biochemical parameters as a risk for CAD in Iraqi population. Methods and Materials : The current case - control study consisted of 300 samples , 150 of them were obtained from CAD patients who underwent the angiography department – heart centre – Al- Hussein Teaching Hospital, Al-Hussein Medical City / Holy Kerbala - Iraq and another 150 healthy control samples. Phenotypic data included body mass index (BMI), levels of fasting blood sugar (FBS), lipid profile, and blood urea, serum creatinine. Genotyping of rs2228570 polymorphism was carried out by PCR–RFLP method. DNA was extracted from genomic whole blood and genotyping was achieved with specific primers to amplify fragments for digestion with restriction enzymes. The enzyme Fok I was used for the digestion of VDR gene product followed by electrophoresis on agarose gel. Various statistical analyses were applied to analyse the data. Result: Digestion of VDR – Fok I gene product (PCR-product ) exhibited an amplicon size of 273 bp, when this amplicon digested with Fok I enzyme, it gives three genotypes indicated one (273bp), two (75 bp + 198 bp) and three (75 bp + 198 bp + 273 bp ) bands for those with wild type (TT), homozygous (CC) and heterozygous (TC) genotypes respectively. Genotype frequencies of rs2228570 polymorphism were found to be consistent with Hardy–Weinberg equilibrium with allele frequencies of TT wild genotype (33.3%), TC heterozygous genotype (46.7%), and CC homozygous genotype (20%) in cases of CAD group while 66.7%, 30 % and 3.3 % for wild, heterozygous, and homozygous in the control group respectively. The homozygous genotype (CC) was significantly (OR= 7.25, CI 2.74-19.20 , P<0.001 ) increased the risk of CAD seven and quarter folds with respect to those of the wild type (TT) after adjustment for age, sex and BMI, while the TC genotype significantly (OR = 2.04, CI 95% ; 1.27- 3.28 , P<0.001) raised the risk of CAD by two folds. Co-dominant genotypes of rs2228570 polymorphism exhibited significant association with anthropometric and biochemical parameters such as BMI, and lipid profile among patients groups as compared with control groups. Conclusion: The obtained results improved that the gene polymorphism of VDR-Fok I was associated with high risk for development and progression of CAD and exhibited a significant association with increased BMI and lipid profile of coronary artery diseases of Iraqi population. Keywords: Coronary artery disease (CAD) ; vitamin D receptor (VDR) ; Fok I.

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The significant ofC677Tmethylenetetrahydrofolate reductase MTHFR gene mutation in Iraqi patients with type 2 diabetic nephropathy

الباحث الأول: Salih M. Al-Khafaji1

الباحثين الآخرين: Anwar M. Al-janabi

المجلة: International Journal of Scientific & Engineering Research

تاريخ النشر: None

مختصر البحث:

Abstract This study aimed to address the association of C677T point mutation of MTHFR gene with Diabetic Nephropathy (DN) in Iraqi type 2 diabetes mellitus patients (DM). We examined age; gender; duration of diabetic, Body mass index, glycosylated …

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Association of HER2 [ILe655Val] gene polymorphism and Breast Cancer Risk in Iraqi females Population

الباحث الأول: Anwar M. Al-Janabi

الباحثين الآخرين: Abdul Hussein Alwan Algenabi1, Talib Hussein Kamoona,Salih M. Alkhafaji

المجلة: International Journal of Advanced Research

تاريخ النشر: None

مختصر البحث:

Abstract Introduction: Breast cancer is progressively more global problem. It is considered the first or second most common cancer and major cause of death in women globally. Human epidermal growth factor receptor (HER-2) is proto-oncogene, a trans…

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Association of TP53 [Arg72Pro] Gene Polymorphism and Breast Cancer Risk in Iraqi female patients

الباحث الأول: Anwar M. Al-janabi

الباحثين الآخرين: Abdul Hussein A. Algenabi*, Salih M. Alkhafaji**, Imad Alsabri

المجلة: International Journal of Scientific & Engineering Research

تاريخ النشر: None

مختصر البحث:

Abstract Breast cancer is considered the first or second most common cancer and major cause of death in women globally. The TP53 tumor suppressor gene is one of the most commonly mutated genes in all types of human cancer including breast cancer. n…

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Heterochromatin Polymorphisms and Chromosomes Damage in Heavy Smoking Men

الباحث الأول: Salih M. Al-Khafaji1,

الباحثين الآخرين: Anwar M. Al-janabi2, Shehab A .Faris1

المجلة: Journal of Biology, Agriculture and Healthcare

تاريخ النشر: None

مختصر البحث:

Abstract: Objective: The goal of the study is to appraise the heterochromatin polymorphism and chromosomal abnormalities associated with chromosome in smoking men. Methods: During a 9-months period (January 2014 to September 2014) a total of 60 h…

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Ribonuclease (RNase) Activity as a Marker to Predict Ovarian Tumors

الباحث الأول: Majjd K. Hussain

الباحثين الآخرين: Anwar. M. AL-Janabi, Jawad. M. Ismael, Abdul Hussasin J. Shamsa & Thualfeqar G. Mohammed

المجلة: GLOBAL JOURNAL OF MEDICAL RESEARCH

تاريخ النشر: None

مختصر البحث:

Abstract – Background : Ribonuclease (RNase) are widely distributed in various organs and body fluids, including serum, urine, saliva, and cerebrospinal fluid. Small amounts of extracellular (( exocrine)) forms of this enzyme are secreted by the nor…

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Evaluation of Serum Ferritin and Iron Status in Pregnant Women of Rural and Urban Areas in Al-Najaf Province

الباحث الأول: Anwar Madlol Al- Janabi

الباحثين الآخرين: Dr. Salih Mahdi Al-Khafaji , Dr. Basemma Al-Ghazali

المجلة: Journal of Babylon University

تاريخ النشر: None

مختصر البحث:

Abstract: Background: Anemia is a major health problem throughout the world, and especially so in developing countries. Women particularly those who are pregnant and lactating, and children are at particular risk. Objective: To …

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انوار مدلول عطيوي الجنابي

انوار مدلول عطيوي الجنابي

الملف الشخصي

البحوث المنشورة

Genetic aspect of Iraqi pregnant women with pre- eclampsia

Connexin 26 (GJB2) gene mutations linked with autosomal recessive non-syndromic sensor neural hearing loss in the Iraqi population

Association of Vitamin D Receptor-FOKI Gene Polymorphism with Breast Cancer Risk in Iraqi Female Patients

Prevalence of Y chromosome microdeletion in azoospermic infertile males of Iraqi population

Polymorphism of Vitamin D Receptor (re2228570) in Sera of Coronary Artery Diseases and its Association with Various Anthropometric and Biochemical Parameters

The significant ofC677Tmethylenetetrahydrofolate reductase MTHFR gene mutation in Iraqi patients with type 2 diabetic nephropathy

Association of HER2 [ILe655Val] gene polymorphism and Breast Cancer Risk in Iraqi females Population

Association of TP53 [Arg72Pro] Gene Polymorphism and Breast Cancer Risk in Iraqi female patients

Heterochromatin Polymorphisms and Chromosomes Damage in Heavy Smoking Men

Ribonuclease (RNase) Activity as a Marker to Predict Ovarian Tumors

Evaluation of Serum Ferritin and Iron Status in Pregnant Women of Rural and Urban Areas in Al-Najaf Province

المحاضرات

OVERVIEW OF ANTIBODIES AND COMPLEMENT SYSTEM Infection and Immunity module

An introduction to infection Infection and Immunity module

ِAn infection models Infection and Immunity module

ACUTE SEPSIS IN THE EMERGENCY DEPARTMENT Infection and Immunity module

HOSPITAL ACQUIRED INFECTIONS Infection and Immunity module

TRAVEL RELATED INFECTIONS Infection and Immunity module

BLOOD BORNE VIRUSES Learning Outcomes Infection and Immunity module

INFECTIONS ON SURFACES Infection and Immunity module

CHRONIC HEALTH AND INFECTIONS Infection and Immunity module

THE IMMUNOCOMPROMISED HOST Infection and Immunity module

Enterobacteriaceae and Some important Helmenthic infections Infection and Immunity module

The Population (Epidemiological) Perspective Health and disease in population

AIDS – the Hidden Epidemic The Health and disease in population

Prevalence Survey Health and disease in population

Measuring Disease in Populations Health and disease in population

Comparing Populations and Mortality Rates Health and disease in population

Sources of Variation Health and disease in population

Cohort Studies Health and disease in population

Case-Control Studies Health and disease in population

Causality: Cause or Merely Association Health and disease in population

Randomised Controlled Trials Health and disease in population

Reviewing the Evidence Health and disease in population

HaDPop Module Revision Issues Health and disease in population