نظام مواقع التدريسيين

Exacerbation of COVID 19 in Hypertensive Patients

الباحث الأول: Noor H. Naser

الباحثين الآخرين: Ammar Abdul Aziz Alibeg

المجلة: Iraqi J Pharm Sci

تاريخ النشر: None

مختصر البحث:

Abstract Since its discovery in December 2019, corona virus was outbreak worldwide with a very rapid rate, so it described by World Health Organization (WHO) as a pandemic. It associated with severe acute respiratory distress syndrome, and can inva…

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Evaluation of the Mixture of phoenix Dactylifera Seeds extract and Chalcone Derivativeas Anti-Angiogenic Agents in Ex-Vivo Rat Aorta Ring Model

الباحث الأول: Samer Ali Hasan1

الباحثين الآخرين: Ammar Abdul Aziz Alibeg2, Zeena Ayad Hussein3

المجلة: Annals of R.S.C.B

تاريخ النشر: None

مختصر البحث:

Abstract: Angiogenesis is very important in the progression of various pathological disorders, most importantly tumor growth and metastasis. This research aims to investigate the efficacy of the synthetic chalcone derivative)2-Hydroxychalcone)and i…

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Design, Synthesis, and Antibacterial Study of New Gatifloxacin-Antioxidants as Mutual Prodrugs

الباحث الأول: Noor H. Nasser

الباحثين الآخرين: Sahar A. Hussein, Ahmed K. Hussein, Ammar A. Alibeg, and Zainab M. Jasim

المجلة: J Biochem Tech

تاريخ النشر: None

مختصر البحث:

Abstract Objective: The objective of this search is to design, and synthesize new mutual prodrugs in order to obtain synergistic antibacterial activity. Methods: The hydroxyl group of three antioxidants (menthol, thymol, and vanillin), was linke…

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Design and Synthesis of Possible Mutual Prodrugs of (Nsaid) Etodolac and Tolmetin with (Cytotoxic) Gemcitabine

الباحث الأول: Ammar Abdul Aziz Alibeg1

الباحثين الآخرين: Abbas H. Abdulsada2, Noor H. Nasser3, Karrar Abdil Aziz Ali beg4

المجلة: Sys Rev Pharm

تاريخ النشر: None

مختصر البحث:

ABSTRACT [NSAIDs] Non-steroidal anti-inflammatory drugs consider an important group of drugs due to their properties as anti-inflammatory and it have both antipyretic and pain killer activities. [COX-II] plays an important role all over oncogenes…

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Design, Synthesis and Preliminary Pharmacological Evaluation of Mutual Prodrug of Non Steroidal Anti-Inflammatory Drugs Coupling with Natural Anti-Oxidants

الباحث الأول: AMMAR ABDUL AZIZ ALIBEG1

الباحثين الآخرين: SAMER A. HASAN2, AHMAD K. HUSSEIN3, NOOR H. NASSER4, KARRAR ABDIL AZIZ ALIBEG

المجلة: International Journal of Pharmaceutical Research

تاريخ النشر: None

مختصر البحث:

ABSTRACT Non steroidalanti inflammatory drugs NSAIDs Etodolac and tolmetin drugs have been coupled with varies natural antioxidants having antiulcerogenicpropertiesin order to get mutual prodrug consist of NSAIDs & antioxidant as a safer NSAIDs wit…

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Design and Synthesis of Possible Mutual Prodrugs of Naproxen and Acetylsalicylic Acid with Gemcitabine

الباحث الأول: Ammar Abdul Aziz Alibeg

المجلة: Journal of Applicable Chemistry

تاريخ النشر: None

مختصر البحث:

ABSTRACT ‘Non-steroidal anti-inflammatory’ (NSAIDs) drugs are most commonly used type of medications and its long period of use result in unwanted side effect like (GI) ulceration. (COX-II) have an important role all over oncogenesis and so I exp…

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Synthesis of Mutual Pro-drugs through coupling of Etodolac And Tolmetin by Sulfa drugs

الباحث الأول: Ammar Abdul Aziz Alibeg

المجلة: AMERICAN JOURNAL OF PHARMATECH RESEARCH

تاريخ النشر: None

مختصر البحث:

ABSTRACT [NSAIDs] “non-steroidal anti-inflammatory drugs” always enter in the management of chronic diseases associated with inflammation, but it have many unwanted side effects, one of them is stomach irritation and ulceration. The Co-drug appr…

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DESIGN AND SYNTHESIS OF NEW DERIVATIVES OF KETOPROFEN LINKED TO NATURAL ANTIOXIDANTS (THYMOL, MENTHOL & GUAIACOL) AS POSSIBLE MUTUAL PRODRUGS

الباحث الأول: Ahmed Kareem Hussein Mubarak

الباحثين الآخرين: Dhurgham Q. Shaheed , Ammar Abdul Aziz libeg, Hayder Kadhium Abbas, Mohammed Dakhil ALRekabi, Ahmed Hashim Husssein اسماء المساعدين:

المجلة: World Journal of Pharmaceutical Research india

تاريخ النشر: None

مختصر البحث:

bstract Non-steroidal anti-inflammatory drugs (NSAIDs) represent one of the most widely used classes of drugs. They are used primarily for the treatment of osteoarthritis, rheumatoid arthritis and other inflammatory disorders. However, the use of NS…

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Synthesis and Antimicrobial Study of Possible Mutual Prodrugs of Amoxicillin and Metronidazole by Direct and Indirect Coupling through Spacer

الباحث الأول: AMMAR A. ALIBEG

الباحثين الآخرين: Ahlam J. Qasir

المجلة: Iraqi Journal of Pharmaceutical Sciences

تاريخ النشر: None

مختصر البحث:

Abstract Amoxicillin have been conjugated with metronidazole as possible mutual prodrug to get a wider spectrum of activity by acting on aerobic and anaerobic bacteria, have antifungal activity, to provide protection for beta lactam ring of amoxici… Abstract Amoxicillin have been conjugated with metronidazole as possible mutual prodrug to get a wider spectrum of activity by acting on aerobic and anaerobic bacteria, have antifungal activity, to provide protection for beta lactam ring of amoxicillin and also to improve patient compliance as it given as a single dose therapy. The structures of the synthesized compound were confirmed and characterized using elemental microanalysis (CHN), IR and some physiochemical properties. Biological study was done by using disc diffusion method against different bacterial strains which are , Staphylococcus aureus , Salmonella typhie , Pseudomonas aeruginosa , E. coli , Klebsiella pneumonia and fungi ( Candida albicans) . using nutrient agar medium and 5 mm diameter paper discs. The synthesized compounds showed maintenance or improvement of the antimicrobial activity especially compound (II) showed superior activity in comparison with compounds (I, III) . في هذا البحث نقوم بربط عقار الاموكسيسيلين مع عقار المترونيدازول كمقدمات دوائية لكي نحصل على فعالية ذات طيف أوسع من خلال عمله على البكتريا الهوائية و اللاهوائية , لديه فعالية ضد الفطريات , توفير حماية لحلقة البيتا لاكتام في الاموكسيسيلين و لتحسين استساغة المريض للعلاج . تم تشخيص المركبات المصنعة باستخدام التحليل الدقيق للعناصر المكونة لها و من خلال الأشعة تحت الحمراء و بعض الخواص الفيزيائية والكيميائية . دراسة الفعالية الحيوية تمت باستخدام طريقة الانبعاث القرصي ضد بعض سلالات البكتريا المختلفة و الفطريات و التي هي Staphylococcus aureus , Salmonella typhie , Pseudomonas aeruginosa , E. coli , Klebsiella pneumonia and Candida albicans . باستخدام وسط مغذي و أقراص ورقية قطر 5 مل . لقد أظهرت المركبات المصنعة تحسنا أو حفاظا على الفعالية المضادة للميكروبات وخصوصا المركب (II) حيث اظهر فعالية عالية مقارنة بالمركبات (I,III) .

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SYNTHESIS AND BIOLOGICAL EVALUATION OF SOME NEWLY SYNTHESIZED SCHIFF BASE DERIVED QUINAZOLINONE AND CINNAMALDEHYDE

الباحث الأول: Abbas H. Abdulsada

الباحثين الآخرين: Ammar Abdul Aziz Alibeg2 , Ali N. Wannas3

المجلة: JOURNAL OF PHARMACEUTICAL NEGATIVE RESULTS

تاريخ النشر: None

مختصر البحث:

The goal of this research is to synthesize novel Schiff base-derived quinazolinone derivatives (4a and 4b) with improved antibacterial activities. Chemical procedures and spectrophotometric (IR and NMR) techniques were used to study and describe th…

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Molecular Docking, Synthesis, Characterization, and Preliminary Cytotoxic Study of Novel 1, 2, 3-Triazole-Linked Metronidazole Derivatives

الباحث الأول: Haider Hassan Alsayad

الباحثين الآخرين: Ammar Abul Aziz Alibeg , Zeyad Kadhim Rad Oleiwi

المجلة: Advanced Journal of Chemistry, Section A

تاريخ النشر: None

مختصر البحث:

In this study, five novel 1,2,3-triazole derivatives linked to metronidazole that target EGRR TK in a non-small cell lung tumor were developed. The reaction of metronidazole propargylic ether derivative as terminal alkyne and aryl azide derivatives …

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Molecular docking, synthesis, characteristics and preliminary cytotoxic study of new coumarin-sulfonamide derivatives as histone deacetylase inhibitors

الباحث الأول: Ammar Abdul Aziz Alibeg

الباحثين الآخرين: Mohammed Hassan Mohammed

المجلة: Wiadomości Lekarskie Medical Advances

تاريخ النشر: None

مختصر البحث:

Wiadomości Lekarskie” is an official journal of the Polish Medical Association published since 1928. The articles published in the monthly include original papers, review papers and case studies.

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Design, Synthesis, Insilco Study and Biological Evaluation of New Isatin-Sulfonamide derivatives by using mono amide linker as possible as Histone Deacetylase Inhibitors

الباحث الأول: Ammar Abdul Aziz Alibeg

الباحثين الآخرين: Mohammed Hassan Mohammed

المجلة: Polski Merkuriusz Lekarski

تاريخ النشر: None

مختصر البحث:

aim: To evaluate the cytotoxic activity of newly synthesized a series of novel HDAC inhibitors comprising sulfonamide as zinc binding group and Isatin derivatives as cap group joined by mono amide linker as required to act as HDAC inhibitors. Materi…

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Design, Synthesis, And Antibacterial Study Of New Gatifloxacin Conjugated With Guaiacol And Paracetamol Analogues As Mutual Prodrug

الباحث الأول: Ahmed Kareem Hussein Mubarak

الباحثين الآخرين: Ammar A. Alibeg,Noor H. Naser and Sahar A. Hussein

المجلة: Nat. Volatiles & Essent. Oils

تاريخ النشر: None

مختصر البحث:

Objective:The objective of the work to design, and synthesize new mutual prodrugs of gatifloxacin to improve the therapeutic action as anti-microbial mainly as anti-bacterial to overcome the emergent anti-bacterial … Objective:The objective of the work to design, and synthesize new mutual prodrugs of gatifloxacin to improve the therapeutic action as anti-microbial mainly as anti-bacterial to overcome the emergent anti-bacterial resistance of the gatifloxacin in first approach and to broaden the anti-bacterial spectrum secondly .In our study we choose the ligand (quaiacol and paracrtamol) to link via an ester bond with gatifloxacin by spacer arm chloroacetyl chloride. The quaiacol is a natural anti-oxidants with mark able anti-bacterial action ,while paracetamol is a centrally non -steroidal anti-inflammatory drugs (NSAIDs) ,the up-to-date studies of paracetamol referred to it hasa good anti-bacterial action. Design of the new analogous of gatifloxacin with quiaicol&paracetamol respectively with complementary anti-bacterial action to synergize the therapeutic action and impair the microbial mechanism of resistance that is the major challenges of the most anti-bacterial antibiotic.Methods: The hydroxyl functional groupe of (quaiacol ,parcetamol), was conjugated to chloroacetyl chloride via a nucleophilic substitution profile reaction respectively, to produce an intermediates (IA-IB), which were further reacted with a carboxyl functional group of Gatifloxacin to produce the designed compounds (I-II) having an ester linkage as mutual prodrug.Results: The Antibacterial activity effect of the designed compounds (I-II) has been investigated for in vitro inhibitory anti-bacterial action against Gram-(+) bacteria like Staphylococcus aureus and Escherichia coli as Gram-negative bacteria; using the diffusion of the spots procedure. All the tested compounds show a remarkable antibacterial activity toward the tested bacteria.Conclusion:The synthesized designated mutual prodrugs were synthesized ,characterized and identified by using FT-IR spectroscopic analysis, 1H-NMR spectroscopic analysis, and important physicochemical properties. The antibacterial assay of the designated compounds report different activities toward the two types of pathogenic bacteria which are Staphylococcus aureus and Escherichia coli. Compounds [I, II] revealed that Staphylococcus aureus was sensitive to synthesized designated compounds but Escherichia coli report a reverse activity with some resistance for antibacterial drugs .

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عمار عبد العزيز عبد الصاحب علي بيك

عمار عبد العزيز عبد الصاحب علي بيك

الملف الشخصي

الاهتمامات البحثية

البحوث المنشورة

Exacerbation of COVID 19 in Hypertensive Patients

Evaluation of the Mixture of phoenix Dactylifera Seeds extract and Chalcone Derivativeas Anti-Angiogenic Agents in Ex-Vivo Rat Aorta Ring Model

Design, Synthesis, and Antibacterial Study of New Gatifloxacin-Antioxidants as Mutual Prodrugs

Design and Synthesis of Possible Mutual Prodrugs of (Nsaid) Etodolac and Tolmetin with (Cytotoxic) Gemcitabine

Design, Synthesis and Preliminary Pharmacological Evaluation of Mutual Prodrug of Non Steroidal Anti-Inflammatory Drugs Coupling with Natural Anti-Oxidants

Design and Synthesis of Possible Mutual Prodrugs of Naproxen and Acetylsalicylic Acid with Gemcitabine

Synthesis of Mutual Pro-drugs through coupling of Etodolac And Tolmetin by Sulfa drugs

DESIGN AND SYNTHESIS OF NEW DERIVATIVES OF KETOPROFEN LINKED TO NATURAL ANTIOXIDANTS (THYMOL, MENTHOL & GUAIACOL) AS POSSIBLE MUTUAL PRODRUGS

Synthesis and Antimicrobial Study of Possible Mutual Prodrugs of Amoxicillin and Metronidazole by Direct and Indirect Coupling through Spacer

SYNTHESIS AND BIOLOGICAL EVALUATION OF SOME NEWLY SYNTHESIZED SCHIFF BASE DERIVED QUINAZOLINONE AND CINNAMALDEHYDE

Molecular Docking, Synthesis, Characterization, and Preliminary Cytotoxic Study of Novel 1, 2, 3-Triazole-Linked Metronidazole Derivatives

Molecular docking, synthesis, characteristics and preliminary cytotoxic study of new coumarin-sulfonamide derivatives as histone deacetylase inhibitors

Design, Synthesis, Insilco Study and Biological Evaluation of New Isatin-Sulfonamide derivatives by using mono amide linker as possible as Histone Deacetylase Inhibitors

Design, Synthesis, And Antibacterial Study Of New Gatifloxacin Conjugated With Guaiacol And Paracetamol Analogues As Mutual Prodrug

المحاضرات

antiviral Organic Pharmaceutical Chemistry III

antineoplastic - alkylating agent Organic Pharmaceutical Chemistry III

antineoplastic - antimetabolite Organic Pharmaceutical Chemistry III

assay of borax Organic Pharmaceutical Chemistry III

Drugs metabolism Organic Pharmaceutical Chemistry I

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