نظام مواقع التدريسيين

البحوث المنشورة

Dimethyl fumarate attenuates liver injury in a mouse model of cecal ligation and puncture by modulating inflammatory, angiogenic and pyroptotic pathways

الباحث الأول: Heider Qassam

الباحثين الآخرين: Ali M. Janabi, Karrar Kareem Gaen & Najah Rayish Hadi

المجلة: BMC Pharmacology and Toxicology

تاريخ النشر: 17 يوليو، 2025

Therapeutic potential of vardenafil in preventing sepsis-induced kidney injury: a preclinical study

الباحث الأول: Ghanim Al-ghanimi

الباحثين الآخرين: Ali M. Janabi

المجلة: Pharmacia

تاريخ النشر: 3 يوليو، 2025

Nephroprotective role of resveratrol in renal ischemia-reperfusion injury: a preclinical study in Sprague-Dawley rats

الباحث الأول: Elaf R. Alaasam

الباحثين الآخرين: Ali M. Janabi, Karrar M. Al-Buthabhak, Rihab H. Almudhafar, Najah R. Hadi, Athanasios Alexiou, Marios Papadakis, Mohammed E. Abo-El Fetoh, Dalia Fouad & Gaber El-Saber Batiha

المجلة: BMC Pharmacology and Toxicology

تاريخ النشر: 28 أكتوبر، 2024

The Relationship between Some Pro-inflammatory Markers and BODE Index in Patients with Chronic Obstructive Pulmonary Disease

الباحث الأول: Yesar MH Al-Shamma

الباحثين الآخرين: Najah R Hadi, Abdullah Elttayef Jasim, Ahmed Abdullah Ajrash Al-Khafaji, Ali M Janabi

المجلة: Systematic Reviews in Pharmacy

تاريخ النشر: None

مختصر البحث:

Chronic obstructive pulmonary disease (COPD) is a common clinical pathological disease characterized by rapid deterioration of lung function. Lack of effective treatment and complete understanding of mechanism of this disease lead to increased incid…

عرض المزيد

A comparative study of anti-atherosclerotic/anti-inflammatory effect of irbesartan and rosuvastatin in hypercholesterolemic male rabbits

الباحث الأول: Murooj L Majeed

الباحثين الآخرين: Hind F Mahdi, Najah R Hadi and Ali M Janabi

المجلة: Journal of Contemporary Medical Sciences

تاريخ النشر: None

مختصر البحث:

Objective: To evaluate the potential protective effect of irbesartan on atherosclerotic progression using rosuvastatin as a positive control. Methods: Twenty local domestic rabbits were randomly divided into four groups, five rabbits per each group… Objective: To evaluate the potential protective effect of irbesartan on atherosclerotic progression using rosuvastatin as a positive control. Methods: Twenty local domestic rabbits were randomly divided into four groups, five rabbits per each group. The first group (I), rabbits were receiving normal diet; the second group (II), rabbits were receiving 2 % cholesterol diet; the third group (III), rabbits were receiving rosuvastatin and 2% cholesterol diet and; the fourth group (IV), rabbit were receiving irbesartan and 2% cholesterol diet. Serum level of cholesterol, triglycerides, LDL, VLDL and HDL were determined after 12 weeks of the study. Serum level of high sensitive C-reactive protein, ICAM1and VCAM1 were measured after 12 weeks of the study. Total antioxidant activity was also determined. Aortic tissue sent for histopathological examination of atherosclerosis lesion. Result: Data of this study have showed that atherogenic diet caused an increase in serum level of TC, LDL, VLDL and TG and a decrease in serum level of HDL. Treatment of rabbits with irbesartan caused substantial decrease in serum lipid profile compared with untreated rabbit receiving atherogenic diet. No significant difference was seen between irbesartan- and rosuvastatin-treated rabbits in all lipid parameters measured with the exception that the HDL level in rosuvastatin-treated rabbits was significantly higher than that of irbesartan-treated rabbits. Rabbit treated with irbesartan showed a significant decrease in the serum level of high sensitive C-reactive protein, ICAM1, VCAM1 and aortic total antioxidant capacity when compared with untreated group. No significant difference was seen between irbesartan- and rosuvastatin-treated rabbits in all these inflammatory parameters measured. Histopathological examination showed that irbesartan decreased atherogenic lesion significantly when compared with untreated rabbits. Conclusion: Irbesartan has a potential protective effect against atherosclerosis via decreasing lipid oxidation and inflammatory mediators. In terms of lipid lowering and anti-inflammatory effects, irebsartan has similar pattern of effectiveness to rosuvastatin.

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Antibacterial Activity of Different Concentrations of Date Vinegar in Comparison to Ciprofloxacin against Multidrug-Resistance Pseudomonas aeruginosa Isolated from Infected Burn

الباحث الأول: Rabeea, Ihsan S

الباحثين الآخرين: Janabi, Ali M.H

المجلة: Anti-Infective Agents

تاريخ النشر: None

مختصر البحث:

Background: Despite recent advances in burns management and antimicrobial chemotherapy, infection continues to be a tricky in the burns. Treatment of a burn infection especially in case of multi-drug resistant Pseudomonas aeruginosa is a big challen…

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Proinsulin C-peptide-mediated signalling and the search for its receptor

الباحث الأول: Ali M H Janabi

المجلة: University of Leicester

تاريخ النشر: None

مختصر البحث:

Proinsulin connecting peptide (C-peptide) joins the A and B-chain of proinsulin and plays an important role in coordinating the folding of insulin. For many years this peptide was simply considered an inert by-product of insulin biosynthesis and was… Proinsulin connecting peptide (C-peptide) joins the A and B-chain of proinsulin and plays an important role in coordinating the folding of insulin. For many years this peptide was simply considered an inert by-product of insulin biosynthesis and was used mainly as an alternative marker for insulin secretion. Recent evidence, however, demonstrates convincingly that C-peptide has biological function and establishes C-peptide as an attractive therapeutic agent to provide protection against chronic diabetic complications. Little is known about C-peptide signalling in pancreatic β cells with studies focussing on antioxidant effects. C-peptide could have protective roles in these cells. For example, pancreatic β cells exposed to immune complexes in type 2 diabetes require protection possibly via C-peptide. Data presented here demonstrate that C-peptide induced a concentration-dependent phosphorylation (activation) of rpS6, at S235/S236 and S240/244, as well as phosphorylation of components of the upstream signalling pathways of rpS6 (ERK1/2, Akt and S6K) in the pancreatic β cell line, INS-1E. C-peptide also caused concentration-dependent increases in phospo-ERK1/2 and phospho-rpS6 (S240/244) in HEK293 and SH-SY5Y, but not in HEK293A. Stimulatory effects of C-peptide on two important intracellular signalling pathways, ERK1/2 and rpS6, can deliver cytoprotective effects and may, therefore, be of potential importance in the treatment of diabetes. A major limitation of current work on C-peptide is that the receptor(s) have not been identified convincingly. Some recent evidence suggests that the orphan GPCR, GPR146, may be the C-peptide receptor. Here, stable overexpression of C-terminally EGFP-tagged GPR146 in HEK293 and HEK293A cells showed predominant membrane localisation of the receptor. However, C-peptide responses in these were unaffected and C-peptide-evoked internalisation/co-localisation of GPR146-EGFP was not observed. An expression cloning approach in Xenopus oocytes was used to screen pools of cDNA library clones for Gαi-evoked responses of C-peptide given the pertussis toxin sensitivity of responses. This approach did not, however, reveal any C-peptide-evoked responses in any of the approximately 130,000 clones screened. Furthermore, the published C-peptide receptor candidates, GPR146 and α-enolase did not respond to C-peptide when expressed in oocytes. Taken together, signalling events in a pancreatic β cell line suggest relevance of C-peptide to events such as cell survival and proliferation. However, the present work provides no evidence that GPR146 is the C-peptide receptor, which still remains elusive.

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Cysteinyl leukotriene receptor antagonist montelukast ameliorates acute lung injury following haemorrhagic shock in rats

الباحث الأول: Ali M Hashim

المجلة: European Journal of Cardio-Thoracic Surgery

تاريخ النشر: None

مختصر البحث:

The aim of this study was to assess the possible protective effect of montelukast against haemorrhagic shock-induced acute lung injury by interfering with inflammatory and oxidative pathways. Acute lung injury following haemorrhagic shock/resuscitat…

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Leukotriene biosynthesis inhibition ameliorates acute lung injury following hemorrhagic shock in rats

الباحث الأول: Ali M Hashim

المجلة: Journal of Cardiothoracic Surgery

تاريخ النشر: None

مختصر البحث:

Hemorrhagic shock followed by resuscitation is conceived as an insult frequently induces a systemic inflammatory response syndrome and oxidative stress that results in multiple-organ dysfunction syndrome including acute lung injury. MK-886 is a leuk…

عرض المزيد عرض البحث

علي محسن هاشم جنابي

الملف الشخصي

الاهتمامات البحثية

البحوث المنشورة

Dimethyl fumarate attenuates liver injury in a mouse model of cecal ligation and puncture by modulating inflammatory, angiogenic and pyroptotic pathways

Therapeutic potential of vardenafil in preventing sepsis-induced kidney injury: a preclinical study

Nephroprotective role of resveratrol in renal ischemia-reperfusion injury: a preclinical study in Sprague-Dawley rats

The Relationship between Some Pro-inflammatory Markers and BODE Index in Patients with Chronic Obstructive Pulmonary Disease

A comparative study of anti-atherosclerotic/anti-inflammatory effect of irbesartan and rosuvastatin in hypercholesterolemic male rabbits

Antibacterial Activity of Different Concentrations of Date Vinegar in Comparison to Ciprofloxacin against Multidrug-Resistance Pseudomonas aeruginosa Isolated from Infected Burn

Proinsulin C-peptide-mediated signalling and the search for its receptor

Cysteinyl leukotriene receptor antagonist montelukast ameliorates acute lung injury following haemorrhagic shock in rats

Leukotriene biosynthesis inhibition ameliorates acute lung injury following hemorrhagic shock in rats

المحاضرات

Cholinergic drugs Pharmacology I

Anticholinergic drugs Pharmacology I

Adrenergic drugs Pharmacology I

Adrenergic antagonists Pharmacology I

Insulin Pharmacology III

Anti-diabetic drugs Pharmacology III

Erectile dysfunction Pharmacology III

Osteoporosis Pharmacology III

Histamine antagonists Pharmacology III

Serotonergic drugs Pharmacology III

Pharmacology III

Pharmacology III

Pharmacology III

Pharmacology III

Pharmacology III

Pharmacology III

Pharmacology III

Pharmacology III

Pharmacology III

Pharmacology III

Pharmacology III

Pharmacology III

Pharmacology III

Pharmacology III

Pharmacology III

Pharmacology III

Pharmacology III

Pharmacology III

Pharmacology III

Pharmacology III