The association between lipoprotein lipase gene polymorphism (rs320) with TG/HDL-c ratio in coronary artery disease a case control study in Al-Najaf.
الباحث الأول:
Mahdi MR Alsahlawi
الباحثين الآخرين:
Muna Abdulridha Al-Barqaawi2
, Ali M. Omara3
, Majid Kadhum Hussain4
, Abdul
Hussein A. Algenabi5
, Ali B. Abulrazzaq
المجلة:
Turkish Journal of Physiotherapy and Rehabilitation
تاريخ النشر:
None
مختصر البحث:
Background: Coronary artery disease (CAD) is the global leading cause of mortality, it develops mainly
from atherosclerotic changes. Lipoprotein lipase (LPL) is the principal enzyme metabolizing chylomicrons
and very low-density lipoprotein, the i…
Background: Coronary artery disease (CAD) is the global leading cause of mortality, it develops mainly
from atherosclerotic changes. Lipoprotein lipase (LPL) is the principal enzyme metabolizing chylomicrons
and very low-density lipoprotein, the impairment of its activity increases the possibility of CAD initiation.
Methods: One hundred CAD patients and 100 apparently healthy controls were included in this study. Serum
lipid concentrations were measured by standard procedures. DNA was extracted and analyzed for the rs320
SNP of LPL gene polymorphism by ARMS-PCR.
Aim: To verify the influence of rs320 single nucleotide polymorphism of LPL gene on the occurrence of
CAD in a sample of Iraqi persons.
Results: Atherogenic serum lipid concentrations were found to elevate significantly in CAD patients in
comparison to the control group. Analysis of the genotypes and allele frequencies demonstrated significantly
increased number of the heterozygous, TG (OR= 2.9, CI95%= 1.34-6.35, P= 0.006), and homozygous, GG
(OR= 11.5, CI95%= 5.27-25.14, P=0.000), genotype carriers in the CAD group with respect to the control
group. The minor allele G was significantly (P=0.000) higher in patients when compared to the control
groups. The estimation of serum lipid concentrations exhibited significantly higher levels of cholesterol,
triglycerides and LDL-C and a lowering of HDL-C concentration concomitant with the GG genotype.
Conclusion: LPL gene polymorphism, rs320, increases the risk of CAD by 2.9 and 11.5 folds in Iraqi
carriers of the TG and GG genotype respectively. Moreover, the G allele elevates the atherogenic serum lipid
concentrations.
Keywords: rs320; LPL; coronary artery disease; ARMS
