ACE gene Polymorphism on Diabetic Type 2 Patients and their Susceptibility to Diabetic Nephropathy
الباحث الأول:
AL-Nahi Alaa Shakir
الباحثين الآخرين:
Al-Barqaawee Murtadha
المجلة:
Indian Journal of Public Health Research & Development
Year : 2019, Volume : 10, Issue : 10
تاريخ النشر:
None
مختصر البحث:
One of diabetic type 2 (T2D) complications is diabetic nephropathy, the glycated hemoglobin, poor diabetic
control, are considered as risk factors for renal damage. current study aim the I/D polymorphism ACE
gene and serum ACE levels may increase …
One of diabetic type 2 (T2D) complications is diabetic nephropathy, the glycated hemoglobin, poor diabetic
control, are considered as risk factors for renal damage. current study aim the I/D polymorphism ACE
gene and serum ACE levels may increase the diabetic nephropathy complications susceptibility in a sample
population of Al-Najaf in Iraq. a total of 90 T2D patients(about 32 without nephropathy and 58 with
nephropathy) and 50 healthy persons, all groups age were>45years old. The ACE I/D polymorphism was
performed by polymerase chain reaction (PCR) using special primers, followed by electrophoresis on 1.5%
agarose gel. we record significant differences between the ACE I/D polymorphism in T2D and control was
(P < 0.01). the DD genotype of ACE I/D polymorphism the risk for T2D increased (OR=7.2 fold), as well as,
the carriers D allele, the risk (OR=0.55). also T2D patients had a significantly higher level in ACE in diabetic
nephropathy(DN) and lower level in T2D without nephropathy if compared with controls (P < 0.01). Our
evident show the carriers DD genotype had more serum ACE levels than carriers II genotype in T2D.
