Predictive Value of C–reactive Protein, Lactate
Dehydrogenase, Ferritin and D-dimer Levels in
Diagnosing COVID-19 Patients: a Retrospective Study
الباحث الأول:
ahmed naseer kaftan
الباحثين الآخرين:
Majid K Hussain 1, Abdulhussein A Algenabi 1, Farah H Naser 2, Muslim A Enaya
المجلة:
Acta Informatica Medica
تاريخ النشر:
None
مختصر البحث:
Background: Since December 2019. millions of people in the world have been affected
with the novel Coronavirus disease-2019 (COVID-19) pandemic, and high economic
impact has affect many countries especially low socioeconomic one like Iraq due to
…
Background: Since December 2019. millions of people in the world have been affected
with the novel Coronavirus disease-2019 (COVID-19) pandemic, and high economic
impact has affect many countries especially low socioeconomic one like Iraq due to
the high cost and limited availability of RT-PCR for diagnosis of COVID-19, so there
should be predictive low cost easily available laboratory tests that can be used before
proceeding to the high cost techniques. Objective: In this retrospective study we aimed
to evaluate the diagnostic accuracy of CRP, ferritin, LDH and D-dimer in predicting
positive cases of COVID-19 in Iraq. Methods: It is a retrospective observational cohort
study based on STARD guidelines to determine the diagnostic accuracy of (CRP, LDH,
ferritin and D dimer) for COVID-19 of electronic medical records of private medical center
in Najaf city, at which 566 individuals were recruited. The investigated subjects were
either in close contact with previously COVID-19 positive patients or have one or more
symptoms of COVID-19. They were categorized into 2 groups, 205 subjects diagnosed
with RT-PCR as COVID-19 negative, and 361 COVID-19 positive patients, results of study
variables of the cohort were recruited from the medical records. Results: Combining
of these parameters had the following findings: CRP + ferritin; AUC: 0.77 with 55%
sensitivity and 97% specificity, Ferritin + LDH; AUC: 0.83 with 65% sensitivity and 92%
specificity, CRP+LDH; AUC: 0.78 with 56% sensitivity and 98% specificity, CRP + LDH
+ ferritin; AUC: 0.85, with 73% sensitivity and 88% specificity, CRP + LDH + ferritin +
D dimer; AUC: 0.85 75% sensitivity and 87% specificity. Conclusion: Combination of
routine laboratory biomarkers (CRP, LDH and ferritin ±D dimer) can be used to predict
the diagnosis of COVID-19 with an accepted sensitivity and specificity before proceeding
to definitive diagnosis by RT-PCR.
