Association of toll-like receptor 4 gene (Thr399Ile) polymorphism with type II diabetes mellitus patients
الباحث الأول:
Ahmed J. Mohammed
الباحثين الآخرين:
Atheer Mohammed Jasim AL-Zurfi Shaden M. H. Mubarak
المجلة:
Wiadomosci Lekarskie
تاريخ النشر:
20 أغسطس، 2025
مختصر البحث:
ABSTRACT
Aim: This study investigates the association of the TLR4 Thr399Ile (rs4986791) polymorphism with T2DM in Iraqi patients and its influence on clinical parameters.
Materials and Methods: A case-control study was conducted on 200 participant…
ABSTRACT
Aim: This study investigates the association of the TLR4 Thr399Ile (rs4986791) polymorphism with T2DM in Iraqi patients and its influence on clinical parameters.
Materials and Methods: A case-control study was conducted on 200 participants (100 T2DM cases and 100 healthy controls). Phenotypic analyses included
fasting blood glucose, HbA1c, lipid profiles, and insulin sensitivity indices. Genotyping of the TLR4 Thr399Ile polymorphism was performed using PCR-RFLP.
Statistical analyses were conducted using SPSS.
Results: The CT and TT genotypes were significantly more frequent in T2DM patients, associated with higher odds ratios (OR=2.40, p=0.003; OR=5.33, p=0.04,
respectively). HDL levels were significantly lower in variant genotypes (p = 0.01). Other clinical parameters showed no significant genotype-specific differences.
Conclusions: The TLR4 Thr399Ile polymorphism is significantly associated with increased T2DM risk and altered HDL levels in Iraqi patients, highlighting its
potential as a genetic marker for early risk assessment.
