Impact of Gene Polymorphism of Lipoprotein Lipase on Atorvastatin Treatment Outcome in Ischemic Stroke Patient in Najaf Governorate.
الباحث الأول:
Sarah Ali Abbas
الباحثين الآخرين:
, Ahmed M. AlMudhafar, Thekra A. Al-Kashwan, Hayder K Hasson, Adhwaa Hameed Jaber, Najah R Hadi,
المجلة:
European Journal of Molecular & Clinical Medicine, Vol 7, .
تاريخ النشر:
1 نوفمبر، 2020
مختصر البحث:
Background: Stroke was commonly identified as a neurologically impairment that occur in
central nervous system on vascular basis as Acute focal injury. Statin (HMG-CoA reductase
Inhibitor), clinical trials in many large scaled shown that in prim…
Background: Stroke was commonly identified as a neurologically impairment that occur in
central nervous system on vascular basis as Acute focal injury. Statin (HMG-CoA reductase
Inhibitor), clinical trials in many large scaled shown that in primary and secondary CVD the
used of statin was declined rates of (CV). Human Lipoprotein Lipase (LPL) gene coding was
place in short arm of chromosome in the p22 region of the same Chromosome and has nine
introns and ten axons. Aim: The aim of the study is to find out effect of LPL gene
polymorphism of response to atorvastatin treatment in patients with ischemic stroke.
Patients and methods: Samples was Picking up from patients’ admission to at Middle
Euphrates Center for Neurological Sciences in the main hospital for measurement of the lipid
profile, molecular analysis study of genotyping and measurement of human lipoprotein lipase
by ELISA technique. Result: There is good response to treatment and the response consider
statistically significant, the best group response to treatment was homozygous mutation then
Heterozygous mutation and the less group response was Homozygous normal, wild.
Conclusion: The effect of drug on serum biomarker not affected by age except HDL (best
result in age<60yr), and not affected by gender and weight state, while in consider to
smoking and Hypertension TG (best response in non-smoker, hypertensive) and VLDL (best
response in smoker, hypertensive) affected and in diabetic state the Cholesterol and TG
affected on response (the best result in non-diabetic). Heterozygous mutation most
distributed then homozygous normal and the less distributed was homozygous mutation.
Key Words: atorvastatin, gene polymorphism, LPL
