مختصر البحث:
Background: The commonest malignancy in females is breast cancer, it become a major health problem affecting women, worldwide. In spite of its increasing incidence, morbidity and mortality are starting to fall; this may belong to evolving ways of di…
Background: The commonest malignancy in females is breast cancer, it become a major health problem affecting women, worldwide. In spite of its increasing incidence, morbidity and mortality are starting to fall; this may belong to evolving ways of diagnosis and treatment. P53 acts as a transcription factor, regulates cell cycle, and hence functions as a tumor suppressor gene. The most potent endothelial cell Mitogen is VEGF emerged as a prognostic marker in patients with several types of cancer including breast cancer. Both markers were proved to be of prognostic value, moreover simultaneous expression of p53 and VEGF has been reported to have the worst bio-pathological profile in breast carcinoma. Although predictive value of the above biomarkers had been well known in previous investigations, relation between these biomarkers in breast cancer is a point to be discussed more specially in our country. Aims: To evaluate the rate of p53 and VEGF immunoexpression in different clincopathological parameters of breast carcinoma, their correlation and co expression in Iraqi females. Materials and Methods: Seventy two breast cancer patients were included to this study which performed in Pathology Department, Faculty of Medicine, University of Kufa, from October 2018 to May 2019. All the cases were collected from Al-Sadder medical city and some of private laboratories in Najaf, they ranging age between22-70 years with a mean of 46.9 years. (LSAB + ) method was used for IHC detection of p53 and VEGF. Results: Sixty two (86.11%) of the cases were of ductal type while 10 cases (13.89%) of lobular type. The detection rate of p53 and VEGF was 36.11% and 58.33 respectively. P53 immunoexpression was significantly different among tumor sizes, but not in other parameters. However, p53 correlated positively with tumor grade and size. There was a significant difference of VEGF immunoexpression among the above histological subtypes, but not within different tumor sizes, grades and age of the patients, meanwhile VEGF was positively correlated with tumor grade and size. Moreover, both biomarkers were positively correlated with each other, and cases co expressing both p53 and VEGF (19.44%) have shown the most unfavorable bio-pathological profile. Conclusions and recommendations: P53 and VEGF immunoexpression have an important role in pathogenesis of breast carcinoma evolution, and their positivity associated with biologically aggressive tumors, thus recommendation for larger prospective study will give better insight about survival and outcomes
