دعاء عامر كاظم سعيداني

The study has been conducted in Animal House/Faculty of Sciences/University of Kufa between December 2022 and February 2022, fifteen female Albino Rats are used. Gentamicin is aminoglycoside antibiotics widely used during pregnancy for treatment the infections . The present study has been intended to show Alfa Feto Protein parameter in serum and the histological effects of gentamicin on pups liver by SEM in female Albino Rats. The females Rats are randomly divided into three main groups, comprising five rats for each group .The control group is given inta peritoneal injection of physiological normal saline and the second and third group are given inta peritoneal injection of gentamicin doses twenty, forty mg/kg/day respectively for 20 days from the first day to the end of experimental allocated for each female.The rats are sacrificed in 20 th (dpc) to study the Alfa Feto Protein parameter in serum and histological effects of gentamicin on pups liver. The physiological study show negative results in all study groups due to absent of malformations in pups and present histological effects in external architecture structure of pups liver compare with control groups. In conclusion; aminoglycoside gentamicin caused histological effects on pupa liver and not absent of malformations in pups due to negative results of Alfa Feto Protein parameter

The study has been conducted in Animal House/Faculty of Sciences/University of Kufa between December 2022 and February 2022, fifteen female Albino Rats are used. Gentamicin is aminoglycoside antibitics widely used during pregnancy for treatment the infections. The present study has been intended to show the histolopathologiacl effects of gentamic in on placenta in female Albino Rats. The females Rats are randomly divided into three main groups, comprising five rats for each group. The control group is given inta peritoneal injection of physiological normal saline and the second and third group are given inta peritoneal injection of gentamicin doses twenty, forty mg/kg/day respectively for 20 days from the first day to the end of experimental allocated for each female.The rats are sacrificed in 20 th (dpc) to study the hitopathological effects of gentamicin on placenta. The histopathlogical study of female rats embryos treated with twenty, forty mg/kg/day of gentamicin have shown degeneration of spongiotrophoblast and congestions in placental labyrinth compare to control group.The scanning electron microscope study show deformation of architecture structure of placental parenchyma. In conclusion; gentamicin caused hitopathological effects on placenta in 20 th (dpc).

The study has been conducted in Animal House/Faculty of Sciences/University of Kufa, fifteen female Albino Rats are used. Dexamethasone is widely used as glucocorticoids for anti inflammation and allergic diseases. The present study has been intended to show the histolopathologiacl effect of dexamethasone on liver and kidneys of female Albino Rats. The females Rats are randomly divided into three main groups, comprising five rats for each group. The control group is given intra peritoneal injection of physiological normal saline and the second and third group are given intra peritoneal injection of dexamethasone doses twenty, forty mg/kg/day respectively for twenty days from the first day to the end of experimental allocated for each female. The rats are sacrificed to study liver and kidneys morphologically and histologically. Dexamethasone doses twenty, forty mg/kg/day caused significant increase (p˂0.05) in relative weights of liver and kidney female rats compare to control group. The histological study on kidneys of female rats treated with twenty dose mg/kg/day of dexamethasone have shown deformation of glomerulus, proximal convoluted tubule degeneration and hemorrhage. While the kidneys from the forty-dose mg/kg/day dose of dexamethasone have shown severely affected, they are appeared enlargement of glomerulus, proximal convoluted tubules degeneration and hemorrhage. The histological study on sections from liver related to female rats treated with twenty dose mg/kg/day of dexamethasone has shows hepatocytes degeneration and hemorrhage. While the liver from the forty-dose mg/kg/day dose of dexamethasone has shown severely affected, they are appeared hepatocyte degeneration and enlargement of nuclei

This study was conducted to detect the prevalence of Hepatitis C virus and Hepatitis B virus of infected Patients. The study was carried out in the period from January (2016) to December (2016). The study included 420 hepatitis C and B virus suspected patients from Al-Hakeem Hospital, AL-Sader Hospital and Middle Euphrates Hospital in AlNajaf Province with gender and age ranged from (<10-70) years old from both sexes. Patients group was found to be 120 patients infected with Hepatitis represented47 Hepatitis C and 73 Hepatitis B the results of the study showed that the highest rate of infection was in HBV. Our study found the male infected with hepatitis(70.7%) and female infected with hepatitis (29.2%) so the male more infection for hepatitis then female, also we found the patients children under <10 years less infected with hepatitis and more age infected with hepatitis 20-29 and followed by age30-39 and 40-49.

الخلاصة شملت الدراسة قياس تركيز هرمونات الدرقية Thyroid hormone ( T3 , T4 ) والهرمون المحفز للدرقية (TSH) اذ تم فحص عينات الدم ل(30) مريضة من النساء اللواتي قد أصبن بمرض فرط الدرقية (Hyperthyroidism) , علما أنه قد تم استبعاد الحوامل والامراض المرافقة الاخرى من الدراسة , ثم تم مقارنة النتائج مع مجموعة السيطرة والتي تضمنت (30) امراة سليمة , واظهرت نتائج الدراسة حصول نقصان في معدل وزن الجسم للنساء المصابات مقارنة مع مجموعة السيطرة و أرتفاع معنوي ( P < 0.05 ) في معدل تركيز هرموني T3 , T4 للنساء المصابات مقارنة مع مجموعة السيطرة وكذلك انخفاض معنوي ( P < 0.05 ) في معدل تركيز هرمون TSH لمجموعة الدراسة مقارنة مع مجموعة السيطرة و انخفاض في معدل تركيز الهيموكلوبين Hb لمجموعة الدراسة مقارنة مع مجموعة السيطرة و كما اظهرت الدراسة زيادة نسبة الاصابة بمرض تضخم الغدة الدرقية في النساء اللواتي تتراوح اعمارهن بين (59–40 ) مقارنة بمجاميع الدراسة

Out of 70 specimens (ear swabs) collected from patient suffering from CSOM, P. aeruginosa was the dominant bacteria with 28% (21 isolates). P. aeruginosa was the commonest bacterial isolated in adult ages group in larger than 10 years old and the proportion of these isolates were increased with the increasing of age and the highest percentage of isolates were seen in the age groups 51 60 years (50%) and 31 40 years (35%). P. aeruginosa isolated in female (60%) higher them in male (40%). Most of isolates show (100%) multiple resistance to Cefotaxime, Amoxicillin, Naldixic acid, Rifampin and Cephalothin, and highly resistance to Gentamycin, Ceftraxone and Cefotaxime (90.4, 90.4, 95.2) % respectively. While resistance of isolates to Ciprofloxacin and Azithromycin append in (2.3 and 4.7) % respectively. The patterns (Ciprofloxacin, Naldixic acid, Cephalothin, Ceftraxone, Cefotaxime, Cefotaxime, Amoxicillin, Rifampin, Gentamycin) represent the highest degree of multiplicity (42.8%) and the patterns (Naldixic acid, Cephalothin, Ceftraxone, Cefotaxime, Cefotaxime, Amoxicillin, Rifampin) represent the lowest degree of multiplicity (9.5%). The resuts of MIC for chemical disinfactants showed that sekulyse inhibit the bacterial growth at the concentration 2 (76.2 %) and 4 (57.1 %), while minudes stopped the bacterial growth at concentration 1 (38.1 %), 2 (47.6 %) and 4 (71.4 %). Skin sept and detolin inhibit bacterial growth at the concentration of 4 (6.3, 42.9) % and 8 (9.5, 14.3) %, respectively. These results showed that minudes is the best detergent for killing P. aeruginosa since it inhibit growth at the MIC (1).