علاء الدين صبحي محسن السلامي

pomegranate peel is widely used in the Middle east as herbal medicine, its action as hepatoprotective agent still remains to be clarified. To understand its influence on liver vital functions, seventy-five male rats (aged 13 – 15 weeks) were divided into 15 categories randomly including 5 rats per category, and were injected with either Thioacetamide(TAA), or administered pomegranate peel (PP) plus injected TAA or administered selenium plus injected TAA or administered with 0.9 percent normal saline solution as a control. The hepatoprotective effect of herbs was evaluated by measuring levels of serum marker enzymes such as alanine aminotransferase (ALT) and aspartate aminotransferase (AST) and measurement hepatocyte growth factor (HGF). The histological studies found that the supplementation of pomegranate peel significantly (p < 0.05) reduced the damaging effects of TAA on the liver. ALT, AST, and HGF levels declined in treatment group due to the hepatic injury induced. A comparative histopathological study of the liver sections different groups demonstrated that the pomegranate peel drives to normal liver architecture suggesting its use as hepatoprotective Alternative medication.

Sesame oil, natural foods rich in active compounds that have been used since ancient times and popular tradition for the treatment of many diseases. Used in the current study, 64 male rats to determine the effect of sesame oil affordable doses of 0.5, 1, and 2 ml divided into 8 groups. The first group as positive control was no treatment for the purpose of controlling with second group was treated material acrylamide as a negative control for the purpose of comparison with the third, fourth and fifth treatment groups textured acrylamide , sesame oil, while the sixth, seventh and eighth groups treated material only sesame oil. And showed the results of the current study significant effect on physiological blood criteria (RBC, WBC, LYM, MONO, GRANO) and hormonal (FSH, LH, Testosterone), as well as the weight of the genitals (Epididymis and testis) , the weight of total body and cells in spermatogenesis processing , especially when the dose of 2 ml when compared with the control. The study concluded that the possibility of the use of sesame oil in improving fertility in humans, especially those who suffer infertility and when eating sesame oil without the emergence of any side effects. INTRODUCTION The plant sesame medicinal plants widely used and popular tradition in the use of alternative medicine in the treatment of many diseases as possible to hurt and injure man on the one hand and on the other hand-energy food high and gives a pair of skin in luxury uses and which has been used since ancient times. Sesame seeds contain important plant compounds from a fixed rate of oil ranges between 41-63% and stop this oil ratio on the breed and the agriculture climate and other factors 1,2 . The seeds also contain proteins by 26% and increased by 12-13% sugars, minerals and vitamins and acids and other compounds where the acidic and acidic sesamin, sesamolin of the most important acids in seeds 3,2 . As a result, the cultivation of sesame (Sesamum indicum) which dates back to Pedalinacea family in different parts of the world has been used in the treatment of many diseases, such as gum and dental disease, laxative for the digestive system and relieve constipation and prevent atherosclerosis, the treatment of the sensitivity of the skin where used a guarantor for the skin from the blazing sun 4,5 . Since the sesame oil is one of the vehicles omega-3 fatty compounds unsaturated therefore considered an important treatment and tonic for memory and has benefits also on the level of sex for women and men. Has used sesame oil relieve pain vaginal dryness associated with menopause and increase the libido in men who ate the occasion of sesame oil with high amounts of energy 6,7 . Interest in studying the effect of chemicals in the gonads as well as increased and then in the fertility of laboratory animals and humans. And that many of these substances occur testicular degeneration and obstruction of the spermatogenesis process 8,9 . It is this material substance Acrylamide, one of the chemicals used in vitro, they are amorphous material, colorless, odorless and molecular weight of 71.09 and chemical form (CH2CHON). It is also a carcinogen and toxic to nerve cells, as well as causing damage to the eye, skin and respiratory system 10 . And because of the long exposure to this substance causes degeneration in the testes and cause also minimize the diameters of seminiferous tubule and damage in germ cells of spermatogenesis drop in the number of sperm cells and abnormalities in the head of the sperm. Therefore, the goal of research to know the effect of sesame oil dosage interoperability with the injection of Acrylamide in laboratory rats at the level of some of the blood criteria physiological and hormonal.

This study was designed to determine the effects of pomegranate peel on various antioxidiants measurements in liver cirrhosis of rats induced by thioacetamide.Fifty-seven male rats aged 13–15 weeks were randomly divided into 15 categories containing 5 rats per category, and were treated with either TAA, PP, or PP plus TAA or Selenium plus TAA or administered with 0.9% physiological saline solution as a control. The hepatoprotective effect of herbs was evaluated by measuring levels of antioxidiant marker enzymes such as Glutathione Peroxidase (GSH-Px) and Superoxide Dismutase (SOD) and measurement Malondialdehyde (MDA). The histological studies were also carried out to support the above parameters by using special stain Haemotoxlin & eosin and using immunofluorescent staining to examine the distribution of DDR2 in the liver. The study found that the supplementation of pomegranate peel significantly (p< 0.05) reduced the damaging effects on the liver by TAA. GSH, SOD increased in the treatment group, but serum MDA level was declined due to the hepatic injury induced. A comparative histopathological research of the liver between different groups demonstrated that pomegranate peel, drive to normal liver architecture suggesting they may use as a hepatoprotective alternative medication

Objective: The objective of the study was to determination the biochemical changes and it’s relationships in each of three infertile groups (Teratozoospermia, infertile normozoospermia compare with fertile normozoospermia). Methods: Samples were collected at the Fertility Center Laboratories in Sadr Medical City, Najaf ,Iraq. Seminal fluid analysis were carried out on the samples, and samples that taken were 37 of Teratozoospermia, 34 of unexplained infertility samples and 17 of control group samples. A serum was then taken for biochemical tests, where vitamin D, vitamin D receptor (VDR), Testosterone, parathyroid hormone (PTH),Protamin enzyame 1( PRM1) by ELISA method and Calcium, Zinc by spectrophotometer test was measured. Results: The result showed a significant decrease (p<0.05) of VD, Ca+2 and Zn+2 levels in both Teratozoospermia and infertile normospermia compared with control group, While significant increased (p<0.05) of PTH and PRM1 levels in both Teratozoospermia and infertile normospermia compared with control group. And the results showed non-significant (p<0.05) in both VDR and testosterone hormone. Conclusion: A significant decrease and increase in the levels of each of above biochemical markers may be causes problem in infertile patients

In this study (120) adult male rats were used. The animals were divided into four groups, three of these groups were the experiment groups that treated with different doses of the fenvalerate (10.125, 21.25, and 42.5 mg/kg) of rats for three time periods were 10 days and 20 day and 30 days and the last group was the control group that gave distilled water. The criteria that have been studied: Blood parameter such as the number of the RBCs and WBCs count, the level of hemoglobin, the packed cells volume (hematocrit) and platelet counts. and biochemical parameter which included glucose, cholesterol, albumin and liver function test ALT and AST and FSH, LH and testosterone hormones and sperm parameter such as the total sperm count and sperm abnormality. The results from hematological parameter indicated significant decrease in all hematological parameter except WBCs count and biochemical parameter showed significant increase in liver function test ALT and AST, glucose, cholesterol and cearatinin and significant decrease in albumin, follicle-stimulating hormone(FSH), luteinizing hormone(LH) and Testosterone hormone. Significant decrease in the total sperm count and live sperm.

Objective : The aim of present study was to estimate the levels of some minerals ( Zn, Se , Ca , Mg , Na and K ).Also relationships between mentioned components and some sperm parameters and the infertility period were studied as well. Material and Methods : This study was performed on human semen specimens obtained from Asthenospermic patients (101 specimens) and Normospermic males (61 specimens) who were attending to the laboratories of Fertility center in ALSader Hospital of ALNajaf ALAshraf city,Iraq during the period extended from December 2009 to September 2010. Results : The results revealed significant decrease (P <0.05) in the concentrations Zn, Se and Ca. A significant increase (P < 0.05) of Na while insignificant difference of Mg and K values were found in Asthenospermic specimens compared with those of Normospermic specimens. Correlation study showed negative relationship between infertility period and sperm motility percent, normal sperm morphology percent and Grad activity A, and positive relationship with Grade activity D. Conclusion : The results showed negative relationship between the abnormal sperm morphology percent and concentration of Se, Na and Ca in seminal plasma . Sperm motility percent correlated positively with Zn and Caconcentrations. The current study concluded that the change in the concentration of some of the elements lead to change parameters and sperm quality in terms of movement