احمد حسون مجيد

Gold(III) N-heterocyclic carbene (NHC) complexes of form [Au(NHC)4Cl2]Cl were synthesized by reaction of KAuCl4 with bis- and tetrakis(imidazolium) salts in the presence of a mild base. Treatment of these complexes with KPF6 afforded four-coordinate AuIII complexes of form [Au(NHC)4](PF6)3. X-Ray crystallography showed the [AuIII(NHC)4]3+ cations in the hexafluorophosphate salts to have a square planar Au(NHC)4 moiety [Au⋯CNHC 2.024(4)–2.082(7) Å]. In the [AuIII(NHC)4Cl2]+ cations in the chloride salts, coordination about Au was tetragonally-distorted octahedral, the axial Au–Cl bonds being substantially longer [Au⋯Cl 3.148(2)–3.693(1) Å] than the equatorial Au–CNHC bonds [Au⋯C 2.024(4)–2.082(7) Å]. NMR and conductance studies suggested that the structures of the complexes seen in the solid state persisted in DMSO solution, except in one case where a chlorido ligand dissociated from [AuIII(NHC)4Cl2]+ to form [AuIII(NHC)4Cl]2+. The AuIII(NHC)4 unit was surprisingly robust. An AuIII complex was found to undergo H/D exchange reactions in D2O solution at 100 °C with no signs of decomposition detectable by 1H NMR spectroscopy. 1H NMR studies showed that various complexes containing AuIII(NHC)4 moieties underwent little or no decomposition when heated at 120 °C in DMSO-d6 for extended periods.

The New ligand of 5-((2,4-dichlorophenyl)azo)-2,2-dimethyl-1,3-dioxane-4,6-dione (DPOD) have been prepared . Three chelate complexes Have also been prepared by reacting this ligand with the metal ions Co (II),Ni(II) and Cd(II). The preparation has been conducted after fixing the optimum conditions of concentration U.V- visible spectra of these complexes solutions have been studied for a range of pH and concentrations which obey Lampert-Beers Law .The structures of complexes are deduced according to mole ratio method which were obtained from the spectroscopic studies of the complex solutions .The ratios of metal: ligand obtained are (1:2) for all complexes ions .(UV-Vis) absorption spectra of ethanolic solution of complexes showed bathchromic shift , as compared with that of free ligand .The infrared spectra of the chelating complexes have been studied ,this may indicate that coordination between the metal ions and the prepered ligand takes place .The conductivity measurements ,the percentage of metal ions of the complexes were determined ,depending on these results , in addition to, the proposed geometrical structures of the complexes of Co (II), Ni(II), Cd(II) ions are octahedral .

In this study, synthesis of 5-benzylidene thiobarbituric acid derivative has been described. The route of preparation involved the uses of thiobarbituric acid as starting material and treated with 4-dimethylaminobenzaldehyde compound to give required derivative. This compound was identified by spectroscopic methods; H NMR, FTIR and CHNS analysis and also by measuring its melting point. A theoretical investigation is performed using hybrid Beck model (B3LYP), ESP showed regular distribution of charge density of whole molecule when one of the two proton is removed from a-carbon, the ESP for HOMO electron density is heavily localized on a negative carbon, reflect the reactivity of thiobarbituric molecule and show it as highly effective nucleophile when act into nucleophilic substitution reactions.

A total of fifty (50) samples were collected from burn infections from AL-Sader Medical City in Alnajaf Alashraf during the period from the 24th of January to the 4th of April . Different percentages of different bacteria were noted as follows , Pseudomonas aeruginosa was the highest percentage about 33% followed by Ps. florescence 8( 16 %) , both E.coli & Klebsiella Sp comprised 6 (12%) ,and Aeromonas sp was the lowest ratio comprising 2% . The most bacteria appeared resistance to antibiotics, Pseudomonas aeruginosa was found to be resistant to most of the therapeutic agents. In this paper a synthesis of 5-benzylidene thiobarbituric acid derivative have been described. The route of preparation involved the uses of thiobarbituric acid as starting material and treated with 4-dimethylaminobenzaldehyde compound to give required derivative this compound have been identified by a spectroscopic method like H-NMR, IR and CHNS analysis and also by measuring its melting point.A simple synthetic route for 5-(4-dimethylaminobenzylidene)thiobarbituric acid by the condensation reaction of 4-dimethylaminobenzaldehyde with thiobarbituric acid in water without catalyst is described. The results revealed that proteus sp. was affected by chemical model more than the other bacteria , increasing the concentration of the compound increases the inhibition zone .also bacteria Klebseilla sp. Pseudomonas aeruginosa. affected by compound model ,but bacteria Staphylococcus arueus was not affected by any concentration of compound. The aim of of this study was to determine the model of chemical compounds effect on the growth of some bacteria isolated from buruns in vitro.

In this paper a synthesis of some new 2,4-dihydroxyquinoline and 4-hydroxycoumarin derivatives have been described. The route of preparation involved the uses of Meldrum’s acid as starting material and treated with different substitution hydroxy and amino aromatic compounds and the product have been cyclized by using polyphosphoric acid . The spectral were used (FT-I.R, 1H-NMR ) and CHN analysis to support the structures of the products. The prepared compounds have been tested against Staphylococcus arueus bacteria.

We report new cyclophanes containing imidazole-2-selone groups linked by xylylene rings. A set of imidazole-2-selone cyclophanes is synthesized by reaction corresponding to imidazolium cyclophanes with selenium in the presence of K2CO3. The structural behavior of the new imidazole-2-selone cyclophanes was determined by 1H and 13C NMR spectra and X-ray diffraction studies. Cyclophanes incorporating o-xylylene or mesitylene-m-cyclophane linked by selone groups were mutually syn in both the solid state and solution, and the cyclophanes showed a conformation similar to the cone conformation of calix[4]arenes. Cyclophanes incorporating p-xylylene or m-xylylene linked by selone groups showed two conformations in the solution: one mutually syn and the other mutually anti. There was no interconversion for both conformations observed on the NMR timescale. In the solid state, three conformations were detected for the p-xylylene-linked cyclophane: one is mutually syn and the other two are mutually anti and partial cone conformations. In the m-xylylene-linked case, only anti-conformation was characterized in the solid state. A density functional analysis was conducted to interpret the stability of the studied compounds and shed light on their origin. The energy preference analysis is in consistent agreement with the observed geometries and their co-existence.

ead the full text About Graphical Abstract Silver(I)-NHC complexes were synthesized by reacting Ag2O with imidazolium salts. These complexes were found to possess significant anticancer potential, particularly in their effectiveness against breast cancer cells. Description unavailable Abstract A new study focused on the synthesis of silver(I)-N-heterocyclic carbene complexes. The mono-Ag(I)-NHC complexes were successfully synthesized in high yield using a direct complexation method, which involved an excess of Ag2O and imidazolium salts (R= butyl, methylacetate) in dichloromethane. The bis-Ag(I)-NHC complexes, on the other hand, were synthesized using a 1 : 2 ratio of Ag2O and imidazolium salts. The ligands and resulting complexes were thoroughly characterized using analytical techniques such as FT-IR, NMR spectroscopy, LC–MS and elemental analysis. Subsequently, the synthesized complexes were tested against MCF7 breast cancer cells. The results of the study highlighted the remarkable anticancer potential exhibited by the Ag(I)-NHC complexes against breast cancer cells. Interestingly, it was observed that the mono Ag(I) NHC complexes demonstrated greater potency, with IC50 values ranging from 5 to 13.5 μg/mL, when compared to their bis-Ag(I)-NHC counterparts.