AbstractRecently emerged, a new form of smoking known as electronic cigarettes. It is being promoted as a healthy alternative to quitting tobacco smoking, is gradually increasing in popularity among teenagers and young adults. the study examines the relationship of electronic smoking to the occurrence of oxidative stress in chronic male smokers by measuring a number of blood parameters and indicators of oxidative stress. The study was conducted on (100) person of males (in good health), ages ranged between (15-44 years), divided into two groups, the first group included (75) ECsmoker. the second group included (25) nonsmoker. The results showed that there was a significant increase (P < 0.05) in (RBC), (WBC) and (PLT) in ECsmokers, while there was no significant difference (P > 0.05) with respect to (HBG-HTC) and showed a significant (P < 0.05) decrease in levels of (TAC), (GSH) and (SOD) while indicated a significant (P < 0.05) increase in levels of (TPP),(MDA) and (OSI) in EC smokers compared to the control group. it also showed the extent to which the effect of electronic cigarettes is related for the age of the user, the period of smoking and the percentage of nicotine used. We conclude that e-cigarettes increase the production of oxidative stress, slightly affect a number of blood parameters and These signs may be a good indicator to impact on health of user.