زينب حسين الحلاوي ( مدرس )
كلية العلوم - الكيمياء
[email protected]
Insulin Resistance in Polycystic Ovarian Syndrome Women: Impact of Regularity and Hyperandrogenemia
بحث النوع:
علوم التخصص العام:
Dr. Zainab Hussein Mohammed اسم الناشر:
Maha Abdul Saheb Ridha Prof. Dr. Hussein Kadhem Al-Hakeim اسماء المساعدين:
journal of pharmaceutical sciences and Research الجهة الناشرة:
vol.11(N 5) in 2019  
2019 سنة النشر:


Polycystic ovary syndrome (PCOS) is the most common endocrine disorder and the main cause of infertility due to anovulation among reproductive-aged women. fetal programming is the beginning of the insulin resistance (IR) and hyperandrogenism which leads to a chain of health consequences. The disturbances in menstruation and fertility develop metabolic complications as age advances. An early and precise diagnosis is necessary for a satisfactory management of PCOS, especially at the extreme ends of the reproductive lifespan. In the present study, IR, hormones and irregularity was studied in PCOS and compared with the control groups. Sixty PCOS women and thirty apparently healthy women were participated in the present study. Serum Fasting serum glucose and sugar, prolactine, progesterone, Cortisol, LH, FSH, estradiol, total & Free testosterone were determined in all women’s. In PCOS women (IR-PCOS) had more obesity comparing with (non IR-PCOS). HOMA%B and insulin were increased while HOMA%S decreased in IR-PCOS patients in comparing with (non-IR-PCOS). The IR-PCOS patients had higher LH/FSH, and BMI and lower FSH than Non IR-PCOS. Serum (Insulin, HOMA%B, LH, LH/FSH) significantly increased in IR-PCOS patients, while serum (FSH, HOMA S%) levels were decreased as compared with non IR-PCOS. Furthermore, IR-PCOS patients had higher PRG, Cortisol, E2, PRL and lower free Testosterone and total Testosterone. In Iraqi women with PCOS, IR state is increased as women having irregular menstruation or hyperandrogenism. Also, PCOS has many changes in hormones and other measured parameters duo to the metabolic bases of the syndrome.