سامر علي علي ( مدرس )
كلية الصيدلة - صيدلة عام
[email protected]
Cytotoxicity and Modulation of Synthesized Nitrochalcone derivative on Rhabdomyosarcoma cell line
بحث النوع:
صيدلة التخصص العام:
Khalida K. Abbas Al-Kelaby اسم الناشر:
Samer A. Hasan and Jawad K. Abbas اسماء المساعدين:
Journal of Cellular Cancer الجهة الناشرة:
Journal of Cellular Cancer  
2016 سنة النشر:


Abstract Many efforts have focused on the therapeutic approach of cancer for a long time by studying of cytotoxic activities of plant constituents. This study was planned to evaluate cytotoxicity of nitrochalcone derivative (NCD) on rhabdomyosarcoma cell line (RMS) as compared with methotrexate (MTX) and Doxorubicin (DOX), then assessment of monoterpene (MT1) combination with NCD. The results of current study were showed that NCD was effectively inhibited the cell proliferation by decreasing the viability of RMS cells at different concentrations involved 0.5, 2.5, 10, 20, 30, 40, 50, 60 and 70 μg/ml with IC50 of 2.117μg/ml, while DOX and MTX IC50 values were 0.553μg/ml and 0.8708μg/ml respectively. This study was also revealed combined effect of NCD with MT1 (IC50 = 2.0667). We concluded that NCD have an anticancer effect that can be modulated by monoterpenes.