سامر علي علي ( مدرس )
كلية الصيدلة - صيدلة عام
[email protected]
Hepatoprotective effects of thyme extract in Cisplatin-induced liver toxicity in rabbits
بحث النوع:
صيدلة التخصص العام:
Ahmed Abu Raghif اسم الناشر:
Ahmed Salih and Samer ali hasan اسماء المساعدين:
Der Pharmacia Lettre الجهة الناشرة:
Der Pharma Lettre A is peer-reviewed and is published in electronic version. The language of the Der Pharma Chemica is English. Der Pharma Chemica publishes research and review articles, rapid and short communication and book reviews. The current emphasis of the journal includes (but is not limited to) the following areas: medicinal chemistry,pharmaceutical chemistry and computational chemistry.  
2016 سنة النشر:


ASTRACT The administration of aqueous thyme extract was investigated for its hepatoprotective effect in rabbits with acute liver injury induced by a single i.p. injection of cisplatin (6.5 mg/kg). Aqueous thyme extract treatment (500 mg/kg/day, orally) was applied for 7 consecutive days, starting 4 days before cisplatin administration. Aqueous thyme extract significantly reduced serum levels of liver enzymes and increased serum albumin levels which were altered by cisplatin. Aqueous thyme extract significantly compensated deficits in tissue glutathione level, suppressed lipid peroxidation, and decreased the elevations of serum tumor necrosis factor-alpha resulted from cisplatin administration. Also, histopathological liver tissue damage mediated by cisplatin as well as inflammatory cells infiltration was greatly ameliorated by aqueous thyme extract treatment. It was concluded that aqueous thyme extract represents a potential therapeutic option to protect against acute cisplatin hepatotoxicity commonly encountered in clinical practice.