| Synthesis of new fluorinated chalcone
derivative with anti-inflammatory activity | | تحميل |
| بحث |
النوع: |
| صيدلة |
التخصص العام: |
| SAMER ALI HASAN |
اسم الناشر: |
| AMER NADHIM ELIAS, AHMAD HAMID JWAIED, ALAA RADI KHUODAER, SAAD ABDULRAHMAN HUSSAIN |
اسماء المساعدين: |
| International Journal of Pharmacy and Pharmaceutical Sciences |
الجهة الناشرة: |
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International Journal of Pharmacy and Pharmaceutical Sciences (Int J Pharm Pharm Sci) is peer-reviewed, monthly (Onward April 2014) open access Journal. IJPPS publishes original research work that contributes significantly to advance the scientific knowledge in pharmacy and pharmaceutical sciences including
Pharmaceutical Technology, Pharmaceutics, Novel Drug Delivery, Biopharmaceutics, Pharmacokinetics
Pharmacognosy and Natural Product Research
Pharmaceutical/Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmaceutical Analysis
Pharmacology, Pharmacy Practice, Clinical and Hospital Pharmacy
Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics, Pharmacoeconomics
Research outcomes from medical sciences/case study and biotechnology of pharmaceutical interest are also considered. |
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| 2012 |
سنة النشر: |
الخلاصة
ABSTRACT
In an effort to synthesize a new fluorinated chalcone derivative with potent anti-inflammatory activity, Claisen-Schmidt condensation method was
followed using SOCl2/ETOH as a catalyst to synthesize (E)-3-(4-fluorophenyl)-1-(4-hydroxyphenyl) prop-2-en-1-one with excellent yield. The
structure of the synthesized compound has been characterized by TLC, melting point, UV, and IR Spectroscopy, and elemental microanalysis
(CHNO). This compound has been evaluated for anti-inflammatory activity using cotton pellet-induced granuloma in rats as a model, and found
comparable to dexamethasone in this regard. |
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| الإهتمامات البحثية |
| التصنيع الدوائي الكيميائي |
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