Benner
صالح مهدي الحفاجي ( أستاذ )
كلية الطب - طب عام
[email protected]
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Genetic Aspect of Iraqi Pregnant Women with Pre-Eclampsia
بحث النوع:
طب التخصص العام:
صالح مهدي الخفاجي اسم الناشر:
انوار مدلول الجنابي& باسمه الغزالي & شهاب احمد فارس اسماء المساعدين:
International Journal of Science and Research (IJSR) ISSN (Online): 2319-7064 الجهة الناشرة:
مجله عالميه (خارجيه)  
2015 سنة النشر:

الخلاصة

Abstract: Introduction: One of serious problems of pregnancy complication is the Pre-eclampsia syndrome (PE) which mostly leads to increase morbidity and mortality in mother and fetus. Objective: we aimed to study and evaluate the genetic polymorphism contribution of MTHFR gene in preeclampsia patients and healthy pregnant women. Methods: We examined maternal age, gestational age, BMI, serum homocysteine concentration,proteinuria,systolic blood pressure, diastolic blood pressure and MTHFR (C677T) gene polymorphism in 52 PE and 50 healthy pregnant women. After DNA extraction from blood samples of all participants the PCR-RFLP technique were applied for detection of MTHFR gene polymorphism. Results:We found the means of serumhomocysteine concentration,proteinuria, systolic blood pressure, diastolic blood pressure which were significantly higher in PE patients compared to healthy control (P˂0.05). The miner allele frequency of T genotype was significantly higher in PE patientsthan the subjects of control groups(P˂0.0001) and the risk of PE was higher by 20.9 folds in homozygous allele genotype(TT) when compared with wild genotype(CC) ( OR 20.9, 95% CI= 4.06- 107.4 P= 0.003). Conclusion:We concluded that the TT genotype of MTHFR gene is increased the risk of PE in pregnant patients of Iraqi population.