Benner
صالح مهدي الحفاجي ( أستاذ )
كلية الطب - طب عام
[email protected]
07801234795
 
 
 
The significance of autosomal C-band size polymorphism in male infertility
بحث النوع:
طب التخصص العام:
عقيل عبد ياسين اسم الناشر:
صالح مهدي الخفاجي اسماء المساعدين:
المجله الطبيه السعوديه الجهة الناشرة:
مجله طبيه متخصصه تصدر في المملكه العربيه السعوديه  
2002 سنة النشر:

الخلاصة

Objective: The aim of this study is to assess the possible role of autosomal C-band size polymorphism in male infertility. Methods: Two-hundred male patients with clinical diagnosis of infertility and 100 normal controls were included in the present investigation. All patients were assessed by Urologist Consultant at the Department of Pathology and Forensic Medicine, Kufa University, Kufa, Iraq, during a 2-year-period, October 1999 to October 2001. C-band evaluation was based on both quantitative and qualitative methods. Blood culture, chromosome harvesting, and C-band technique were carried out according to standard methods. From the Department of Pathology and Forensic Medicine (Yasseen), Middle Euphrates Center for Cancer Research and the Department of Anatomy (Al-Khafaji), College of Medicine, Kufa University, Kufa, Iraq. Received 10th March 2002. Accepted for publication in final form 24th August 2002. Address correspondence and reprint request to: Prof. Akeel A.Yasseen, Department of Pathology and Forensic Medicine, Kufa University, PO Box 18, Kufa, Iraq. Fax. +964 33360328. E-mail: [email protected] Results: 1. C-band quantitative study indicates a significant increase in the C- band size of chromosomes 9 and 16 among infertile groups as compared to normal fertile group (p<0.01). 2. C-band qualitative study indicates a significant increase in the C-band size (level 3) of chromosome number one among the infertile group as compared to normal fertile group (p<0.01). Conclusion: The present findings require further extensive study to shed light on the possible correlation between C-band polymorphism and male infertility. Saudi Med J 2002; Vol. 23 (12): 1473-1477