Benner
صادق حسن الشميساوي ( مدرس )
كلية الصيدلة - صيدلة عام
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Semisolid Dosage Form of Phenytoin Sodium
تحميل
بحث النوع:
صيدلة التخصص العام:
Maiada M Almousilly اسم الناشر:
, Loay k Abdulrahman , Sadiq H. Alshmesawy, and Fatima A. Tawfiq اسماء المساعدين:
INTERNATIONAL RESEARCH JOURNAL OF PHARMACY الجهة الناشرة:
IRJP 2012, 3 ( 11 ) Page 71-74 INTERNATIONAL RESEARCH JOURNAL OF PHARMACY www.irjponline.com ISSN 2230 – 8407 Article Received on: 14 /09/12 Revised on: 0 1/10/12 Approved for publication: 10 /11/12 RJP is an official publication of Moksha Publishing House. Website: www.mokshaph.com. All rights reserved.  
2012 سنة النشر:

الخلاصة

ABSTRACT Phenytoin sodium was formulated in a solid dosage form using different bases; o/w emulsion base, water soluble base, oleagino us base, and vanishin g cream base. Base s were prepared in two different concentrations, 5 % and 10 % w/w . The diffusion of the drug from each of the above bases was investigated. Results indicated that the effect of the type of ointment base on the release rate of phenytoin sod ium is significant. The rate and extent of phenytoin sodium release and diffusion through mouse skin was higher from the water soluble base (10% w/w) compared to other ointment bases, the difference was highly significant (P< 0.05).