الخلاصة

Subjects: During six years ago, 109 patients with malignant colon cancers at metastasis stages (II to IV stages), 112 patients "as a pathological control group", and 85 healthy individuals were enrolled in the present work. CLEC4E, CEA, CA 19-9, and Serotonin levels were measured in the sera of study individuals using sandwich ELISA technique. Results: Current study demonstrated significant increase in the levels of CLEC4E, CEA, and CA 19-9 in the malignant colorectal cancers comparison to pathological controls as well as healthy individuals. Serotonin levels were seemed to be lower at cancerous patients comparison to healthy controls. Conclusions: CLEC4E may be used as a definitive diagnostic marker for cancers than other nonmalignant diseases, moreover CLEC4E and serotonin can be considered as new diagnostic tools for colon cancer and are highly effective follow-up tools and can be diagnostic and follow-up tools when measured with other resident parameters. Measured parameters (CLEC4E, CEA, CA19-9, and Serotonin) can be effective screening tools when diagnosing tumor infections in the colon.