الخلاصة

This research Involved synthesis of some new azetidinone Derivatives from Azo Compound[4-Amino-3--((4- methoxy-2-nitrophenyl)diazenyl)-N-(Pyrimidine-2-yl)benzen-esulfonamide](N1)by two routsone of them Conversion the free amino group in an azo comp. to Schiff base, then formation of azetidinone derivatives by keten-imine reaction or Staudinger's Cyclo addition .The other rout is the cyclization by reaction of the free amino group with Chloro acetyl chloride and Et3N to give Ν-Chloroacetamide derivative then reaction with hydrazine hydrate to produce the hydrazinyl acetamide derivative. Then conversion to Schiff base and finally formation azetidinone derivative. Most of these derivatives were confirmed by "FT-IR,1HNMR and 13CNMR" spectra and by Mass spectrum for two prepared derivatives. the prepared compounds are tested as anticancer and antimicrobial activity against of bacteria and fungi