Benner
د. رعد عبد العباس الهرموش ( أستاذ مساعد )
كلية العلوم - البيئة والتلوث ( مسؤول شعبة )
[email protected]
07726778708
 
 
 
Detection of Efflux Pumps Genes in Clinical Isolates of Acinetobacter baumannii
تحميل
بحث النوع:
علوم التخصص العام:
Raad Abdulabass AL-Harmoosh اسم الناشر:
Eman M. Jarallah, Anmar M. AL-Shamari, Hussein M. AL-Khafaji اسماء المساعدين:
Research J. Pharm. and Tech الجهة الناشرة:
Journal : Research Journal of Pharmacy and Technology Volume No. : 10 Issue No. : 12 Year : 2017 Pages : 4231-4236 ISSN Print : 0974-3618 ISSN Online : 0974-360X  
2017 سنة النشر:

الخلاصة

One of the most interesting features of Acinetobacter baumannii is the ease by which it can acquire resistance to various antibiotics. Mutations, new gene acquisitions, up-regulating expression of existing genes (should those be genes of drug-destroying enzymes or efflux pumps), or losing them, like in the case of porins, all may contribute to the broad spectrum resistance of these strains.This study was directed to decide the event of efflux pumpsgenes harboring A. baumannii isolates recovered from Babylon hospitals. Isolates were recognized by biochemical tests and more affirmed utilizing API 20E system. Antibioticssusceptibility was measured by utilizing disks diffusion test. Ten (0.76%) A. baumannii isolates were recovered from clinical specimens. One (10%) isolate was observed to be imipenem and meropenem resistant (MIC > 512 µg/ml). There are indicative appearance of efflux pump genes ; (50%) for Ade-A and Ade-B each other , (40%) for Ade-C, (80%) for all of Ade-R and Ade-S , (100%) for all of Ade-I and Ade-J , and (50%) for Ade-Y. All isolates of A. baumannii appear as MDR , while only one appear to be as PDR.