الخلاصة

Non-steroidal anti-inflammatory drugs represent one of the most widely used classes of drugs, and are used primarily for the treatment of osteoarthritis, rheumatoid arthritis and other inflammatory disorders; however, the use of NSAIDs is significantly limited by their ability to induce the formation of erosions and ulcers in the gastrointestinal (GI) tract. The analgesic effects of NSAIDs are ascribed primarily to COX-2 inhibition, whereas several adverse effects are believed to be mediated by COX-1 inhibition. Preferential inhibition of COX-2 is thought to be due to the additional space in the COX-2 hydrophobic channel, as well as to the presence of a side pocket in the channel. Therefore, a group of amine derivatives (4-aminobenzenesulfonamide derivatives, 2-aminopyridine and 2-aminothiazole) incorporated in the