Benner
ميادة فرحان جلالده ( أستاذ مساعد )
كلية العلوم - علوم الحياة
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The Role of Interferon- Gene Polymorphism in Spontaneous Abortion
تحميل
بحث النوع:
علوم التخصص العام:
Fatima A. AL-Timimi, اسم الناشر:
Mayyada F. Darweesh, Ali R. Hussein اسماء المساعدين:
International Journal of Scientific & Engineering Research, Volume 5, Issue 12, December-2014 ISSN الجهة الناشرة:
IJSER © 2014 , Volume 5, Issue 12, December-2014International Journal of Scientific & Engineering Research,  
2014 سنة النشر:

الخلاصة

20-22 weeks of pregnancy causing dangers to the mother and her fetus. In recent years, a lot of studies suggest that recurrent abortion is caused by the genetic factors. Aim: The aim of this study was to investigate the association of the IFN- +874T/A polymorphisms and level with spontaneous abortion. Methods: The study group comprised 60 women with spontaneous abortion, and the control group consisted of 30 healthy delivered women. IFN-  Gene polymorphism was detected by ASO-PCR technique and blood level was estimated by ELISA. Results: The frequency of TT genotype (35%) and T allele (55.83%) was significant higher (P<0.05) in the abortion group than in the control group (13.33%, 35% respectively), also, IFN- level was significantly (P<0.01) higher in abortion group (8±0.4 IU/ml) than in control group (1.3±0.07 IU/ml). Conclusions: This study concluded that the IFN- +874T/A polymorphisms (TT genotype) and high IFN- level may be associated with