الخلاصة

Background and Objectives:-The study was done to investigate the level of biomarkers in male mice asthma models induced by Ovalbumin such as periostin and Galectin -3 and Interleukin -33 levels in serum as predictive indicators of the disease for detection, diagnosis and early treatment of disease. Materials and Methods:-In the current study ninety one of male mice weighting (25-30 g) aged (15-17)weeks at the animal house faculty of science/university of Kufa during the period from January 2017 to September 2017. This study included some physiological criteria to evaluate the protective role of omega-3(2 and 3 mg/kg) and silver nanoparticles (5 and 10 mg/kg) against asthma that induced by ovalbumin.The animals experimental are divided into 16 groups (n= 6 mice per each group) for duration of one and two months. Results:-The result sowed significant increase(p<0.05) in the serum level of periostin and Galectin -3 and Interleukin -33 in asthma group as compared with control group. The results of protective group(for 21 days) also showed a significant decrease (p<0.05) in leukocyte count in the group of omega-3 and silver nanoparticles for 21 days after treatment by ovalbumin induced in mice. The results indicated a significant increase (p<0.05) in the serum level of Periostin, Galectin -3 and Interleukin -33 in asthma group as compared with control group, while, there was a significant decrease (p<0,05) in the serum level of periostin and galectin-3 and interlukiune -33 in the treated groups with omega-3 and silver nano particles as compared with asthma group. Conclusion:-The present study concluded that omega-3 and silver nano particles had a protective and treated effect on asthma disease that induced by ovalbumin