Benner
ليلى علي صالح ( أستاذ مساعد )
كلية التربية للبنات - الكيمياء
[email protected]
 
 
 
Synthesis, Spectroscopic and Characterization of some transition metal complexes whit New heterocyclic(Azo -Schiff base) ligand Derived from 4-amino antipyrine and Study of the Biological screening of the gold complex as anticancer
بحث النوع:
علوم التخصص العام:
Layla Ali Mohammed اسم الناشر:
Raheem Tahir Mehdi,and Abid Allah Mohammed Ali اسماء المساعدين:
Nano Biomed Eng.2018 vol.10,Iss3 الجهة الناشرة:
Nano Biomed Eng.2018 vol.10,Iss3  
2018 سنة النشر:

الخلاصة

Abstract: Anew (azo-schiff base) ligand (N1Z,N2Z)-N1,N2-bis(4-((Z)4-hydroxy naphthalen-1-yl)diazenyl)-(1,5-dimethy-2-phenyl - 1H-pyrazol-3(2H)-ylidene) benzene - 1, 2- di amine) has been synthesized from coupling (N1Z,N2Z)-N1,N2- bis(4-amino-1,5-dimethyl-2-phenyl-1H-pyrazol-3(2H)-ylidene)benzene-1,2-diamine with (1-naphthol). The structures of the new ligand and their transition metal complexes are investigated and characterized using different physicochemical studies as elemental analysis, IR spectra, 1HNMR, 13 CNMR, UV-Vis spectra, mass spectra, Molar conductance ,and magnetic susceptibility . The complexes were found to have the general formula [MLCl2] where M = Co(II), Ni(II), Cu(II) ,Zn(II),Cd(II) and Hg(II), [ML]Cl3 where M=Au(III) and[MLCl2] Cl ,where M=Fe(III). The IR results demonstrate that the co-ordination sites are the azomethine nitrogen and azo nitrogen atoms of the( azo-Schiff base) ligand. The electronic spectral and magnetic measurement data indicate that the complexes exhibit octahedral geometry, except the Au(III) complex suggest a square planar geometry around the central metal ion. The biological screening effect of the gold complex are tested against human colon cancer cell line LS-174. The results show the highest inhibitory effect for complex.